Abstract
Very high levels of SGOT (1710, 2450 and >1250) and LDH (1275, 1740 and 1300) are reported in 3 cases of extrahepatic obstruction due to gallstones. The diagnoses were established at operation, and viral hepatitis was ruled out by liver biopsy. Marked SGOT elevations in extrahepatic biliary obstruction are rare, but isolated case reports and experimental biliary obstruction in animals support the observation that SGOT values in excess of 1000 units can occur as a result of the obstructive process.
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Mossberg SM, Ross G: High serum transaminase activity associated with extrahepatic biliary disease. Gastroenterology 45:345, 1963
Abbruzzese A, Jeffery RL: Marked elevations of serum glutamic oxalacetic transaminase and lactic dehydrogenase activity in chronic extrahepatic biliary disease. Amer J Dig Dis 14:332, 1969
Zimmerman HJ, West M: Serum enzymes in gastrointestinal disease. Med Clin N Amer 48:189, 1964
Aronsen KF: Liver function studies during and after complete extrahepatic biliary obstruction in the dog. Acta Chir Scand Suppl 275:1, 1961
Hallberg D, Jonson G, Reichard H: Serum alkaline phosphatases, transaminases, and ornithine carbamyl transferase in biliary obstruction: preliminary report on experiments in the dog. Acta Chir Scand 120:251, 1960
Mossberg SM, Bloom A, Berkowitz J, et al: Serum enzyme activities following morphine: a study of transaminase and alkaline phosphatase levels in normal persons and those with gallbladder disease. Arch Intern Med (Chicago) 109:429, 1962
Burckhardt D, Ladue JS: Provocation of serum enzyme activity in cholecystectomized patients given opiates. Amer J Gastroent 46:43, 1966
Mann FC, Bollman JL: The relation of the gallbladder to the development of jaundice following obstruction of the common bile duct. J Lab Clin Med 10:540, 1924
West M, Zimmerman HJ: Serum enzymes in hepatic disease. Med Clin N Amer 43:371, 1959
Wroblewski F, Ladue JS: Serum glutamic pyruvic transaminase in cardiac and hepatic disease. Proc Soc Exp Biol Med 91:569, 1956
Foulk WT, Fleisher GA: Serum glutamic-oxalacetic transaminase in acute pancreatitis. Gastroenterology 35: 375, 1958
Chinsky M, Sherry S: Serum transaminase as a diagnostic aid. Arch Intern Med (Chicago) 99:556, 1957
Dunn M, Martins J, Reissman KR: The disappearance rate of glutamic oxalacetic transaminase from the circulation and its distribution in the body's fluid compartments and secretions. J Lab Clin Med 51:259, 1958
Linde S: On the mechanism of the elevation of serum glutamic-oxalacetic transaminase in obstructive jaundice. Scand J Clin Lab Invest 10:308, 1958
Hauss WH, Leppelmann HJ: Reactive changes in enzyme activities in serum and liver as symptoms of “acute syndrome.” Ann NY Acad Sci 75:250, 1958
Wroblewski F: Remarks on the significance of changes in serum transaminase levels. J Atheroscler Res 3:740, 1963
Henry L: Serum transaminase levels in liver disease. J Clin Path 12:131, 1959
Goldstein F, Seligson D, Nemir P Jr: The differentiation of medical from surgical jaundice by means of serum transaminase and iron determinations. Surg Forum 9:510, 1958
Rosalki SB: Transaminases in liver disease, Proc Roy Soc Med 53:199, 1960
Sommerville RL, Fleisher GA, Dearing WH: Serum transaminases in hepatic disease. Gastroenterology 39:574, 1960
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Supported by NIH Grant TI AM 5476, US Public Health Service.
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Ginsberg, A.L. Very high levels of SGOT and LDH in patients with extrahepatic biliary tract obstruction. Digest Dis Sci 15, 803–807 (1970). https://doi.org/10.1007/BF02236040
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DOI: https://doi.org/10.1007/BF02236040