Abstract
The relationship between lymph node metastases and postoperative prognosis in 209 patients with early gastric cancer was studied. As to the postoperative prognosis in relation to the extent of lymph nodes dissection, no significant difference was observed among the age-corrected 5-year survival rates following three surgical procedures in patients with early gastric cancer. Age-corrected 5-year survival rates were 0.92±0.44 R1-resection, 0.95±0.44 in R2-resection, and 1.00±0.06 in R3-resection, respectively. In addition, in 71 patients including 33 with early gastric cancer and 38 patients with advanced but relative early gastric carcinoma, the relationship between the immunostatus and postoperative prognosis was investigated. Postoperative age-corrected 5-year survival rate (0.904±1.153) of the optimal responders with good immunostatus was significantly higher than that (0.582±1.153) of the suboptimal responders with impaired immunostatus (P<0.01). Thus, conservative surgery for regional lymphadenectomy may be an effective procedure for cure of early gastric carcinoma, particularly in cases of a carcinoma limited to the mucosal area of the stomach.
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References
The General Rules for the Gastric Cancer Study in Surgery and Pathology. Jpn. J. Surg. 11: 127–145, 1981.
Tsakraklides, V., Anastassiades, O.T. and Kersey, J.H.: Prognostic significance of regional lymph node histology in uterine cervical cancer. Cancer 31: 860–868, 1973.
Kojima, O., Fujita, Y., Oh, A., Sakita, M., Nishioka, B. and Majima, S.: Immunomorphologic study of regional lymph nodes in cancer: Response of regional lymph node cells from gastric and colorectal cancer to PHA stimulation. Jpn. J. Surg. 10: 212–220, 1980.
Yasuna, O., Yamaura, Y., Ogiwara, M., Hatayama, Y., Kusano, M. and Nakamura, K.: Results of surgical treatment of early gastric cancer. Gan no Rinsho (Jpn. J. Cancer Clin.) 25: 1040–1045, 1979. (English Abst.)
Kidokoro, T.: Frequency of resection, metastasis and five-year survival rate of early gastric carcinoma in surgical clinic. In Early Gastric Cancer, Gann Monograph on Research 11, edited by T. Murakami: pp. 45–49, University of Tokyo Press, Tokyo, 1972.
Murakami, T.: Early cancer of the stomach. World J. Surg. 3: 685–692, 1979.
Hayashida, T. and Kidokoro, T.: End results of early gastric cancer collected from 22 institutions. I to Cho (Stomach and Intestine), 4: 1077–1085, 1969, (English Abst.)
Matsusaka, T., Kodama, Y., Soejima, K., Miyazaka, M., Yoshimura, K., Sugimachi, K. and Inokuchi, K.: Recurrence in early gastric cancer. Cancer 46: 168–172, 1980.
Sakita, M., Nishimura, Y., Takenaka, A., Kojima, O., Nishioka, B., Fujita, Y. and Majima, S.: Regional lymphadenectomy and tumor curability in C3H/He mice transplanted with MH134. Tohoku J. Exp. Med. 127: 133–141, 1979.
Fisher, B. and Fisher, E.R.: Studies concerning the regional lymph node in cancer. I. Initiation of Immunity. Cancer 27: 1001–1004, 1971.
Fisher, B. and Fisher, E.R.: Studies concerning the regional lymph node in cancer II. Maintenance of immunity. Cancer 29: 1496–1501, 1972.
Crile, G. Jr.: Rationale of simple mastectomy without radiation for clinical stage I cancer of the breast. Surg. Gyn. Obst. 120: 975–982, 1965.
Edwards, M.H., Baum, M. and Magarey, C.J.: Regression of axillary lymph nodes in cancer of breast. Brit. J. Surg. 59: 776–779, 1972.
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Fujita, Y., Nishioka, B., Sakita, M. et al. Conservative surgery for regional lymphadenectomy in the treatment of early gastric carcinoma. The Japanese Journal of Surgery 13, 184–190 (1983). https://doi.org/10.1007/BF02469474
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DOI: https://doi.org/10.1007/BF02469474