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Selenium depletion in patients on home parenteral nutrition

The effect of selenium supplementation

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Abstract

Severe selenium (Se) depletion was found in nine patients receiving long-term home parenteral nutrition because of short bowel syndrome. Plasma Se ranged from 0–0.51 (median 0.21 μmol/L) and erythrocyte Se ranged from 0.7–2.6 (median 1.8 μmol/gHgb), which was significantly lower than in the controls. Glutathione peroxidase (GSHPx) in plasma and erythrocytes was also decreased.

After bolus injections with 200 μg Se/d in the form of sodium selenite for 4 mo, followed by 100 μg/d for 8 mo, plasma Se increased to values slightly but significantly higher than in the controls. Erythrocyte Se reached normal levels in most of the patients after 4 mo substitution, but it remained lower than in the controls. Following Se supplementation, plasma and erythrocyte GSHPx did not differ between patients and controls. These data suggest that all patients receiving long-term parenteral nutrition because of short bowel syndrome should receive at least 100 μg sodium selenite/d when given as bolus injections to avoid Se depletion.

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Authors and Affiliations

  1. Medical Department A, Division of Gastroenterology, Rigshospitalet, Denmark

    T. Rannem, K. Ladefoged, E. Hylander, J. Hegnhøj & S. Jarnum

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  1. T. Rannem
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  2. K. Ladefoged
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  3. E. Hylander
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  4. J. Hegnhøj
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  5. S. Jarnum
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Rannem, T., Ladefoged, K., Hylander, E. et al. Selenium depletion in patients on home parenteral nutrition. Biol Trace Elem Res 39, 81–90 (1993). https://doi.org/10.1007/BF02783812

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  • DOI: https://doi.org/10.1007/BF02783812

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