Summary
1. Thirteen subjects with diabetes mellitus were used in a clinical study of the secretin test.
2. The observed deviations from the control group of four patients were diminutions in volume of secretion and total secretion of bicarbonate and the enzymes, amylase and trypsin. With one exception these changes were confined exclusively to those patients who had the disease for 3 years or longer.
3. These abnormalities of the duodenal-pancreatic juice could be correlated only with the duration of the disease and not with the age of the patient, the severity of the disease, the presence or absence of acidosis, the amount of insulin required or the diet.
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This work was done under a grant from the research funds of the Horace H. Rackham School of Graduate Studies.
Read at the Annual Meeting of the American Gastro-Enterological Association at Atlantic City, N. J., June 8-9, 1942.
An erratum to this article is available at http://dx.doi.org/10.1007/BF03002305.
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Pollard, H.M., Miller, L. & Brewer, W.A. The external secretion of the pancreas and diabetes mellitus. Journ. D. D. 10, 20–23 (1943). https://doi.org/10.1007/BF02997405
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DOI: https://doi.org/10.1007/BF02997405