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Primary implantation of polyester-covered stent-grafts for transjugular intrahepatic portosystemic stent shunts (TIPSS): A pilot study

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Abstract

Purpose: To investigate whether placement of a polyester-covered stent-graft increases the primary patency of trans-jugular intrahepatic portosystemic stent shunts (TIPSS).

Methods: Between 1995 and 1997 Cragg Endopro or Passager MIBS stent-grafts were used for the creation of TIPSS in eight male patients, 35–59 years of age (mean 48 years). All patients suffered from recurrent variceal bleeding and/or refractory ascites due to liver cirrhosis. Seven stent-grafts were dilated to a diameter of 10 mm, one to 12 mm. Follow-up was performed with duplex ultrasound, clinical assessment, and angiography.

Results: The technical success rate for creation of a TIPSS was 100%. The mean portosystemic pressure gradient decreased from 25 mmHg to 12 mmHg. In seven of eight patients TIPSS dysfunction occurred between 2 days and 3 years after stent-graft placement. In one patient the TIPSS is still primarily patent (224 days after creation). The secondary patency rates are 31 days to 3 years.

Conclusion: The primary use of polyester-covered stent-grafts for TIPSS did not increase primary patency rates in our small series.

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References

  1. Stanley AJ, Jalan R, Forrest EH, Redhead DN, Hayes PC (1996) Longterm follow up of transjugular intrahepatic portosystemic stent shunt (TIPSS) for the treatment of portal hypertension: Result in 130 patients. Gut 39:479–485

    Article  PubMed  CAS  Google Scholar 

  2. Rössle M, Haag K, Ochs A, Sellinger M, Nöldge G, Perarnau JM, Berger E, Blum U, Gabelmann A, Hauenstein K, et al. (1994) The transjugular intrahepatic portosystemic stent-shunt procedure for variceal bleeding. N Engl J Med 330:165–171

    Article  PubMed  Google Scholar 

  3. Saxon RR, Barton RE, Keller FS, Rösch J (1995) Prevention, detection, and treatment of TIPSS stenosis and occlusion. Semin Intervent Radiol 12:375–383

    Article  Google Scholar 

  4. Haskal ZJ, Pentecost MJ, Soulen MC, Shlansky-Goldberg RD, Baum RA, Cope C (1994) Transjugular intrahepatic portosystemic shunt stenosis and revisions: Early and midterm results. AJR 163:439–444

    PubMed  CAS  Google Scholar 

  5. Latimer J, Bawa SM, Rees CJ, Hudson M, Rose JDG (1998) Patency and reintervention rates during routine TIPSS surveillance. Cardiovasc Intervent Radiol 21:234–239

    Article  PubMed  CAS  Google Scholar 

  6. Saxon RR, Mendel-Hartvig J, Corless CL, Uchida BT, Nishimine K, Keller FS (1996) Bile duct injury as major cause of stenosis and occlusion in TIPSS shunts: Comparative histopathologic analysis in humans and swine. J Vase Interv Radiol 7:487–497

    Article  CAS  Google Scholar 

  7. Saxon RR, Timmermans HA, Uchida BT, Petersen BD, Benner KG, Rabkin J, Keller FS (1997) Stent-grafts for revision of TIPS stenoses and occlusions: A clinical pilot study. J Vase Interv Radiol 8:539–548

    Article  CAS  Google Scholar 

  8. Barton RE, Rösch J, Saxon RR, Lakin PC, Petersen BD, Keller FS (1995) TIPSS: Short- and long-term results. A survey of 1750 patients. Semin Interv Radiol 12:364–367

    Article  Google Scholar 

  9. LaBerge JM (1995) Histology of transjugular intrahepatic portosystemic shunts. Semin Interv Radiol 12:384–388

    Article  Google Scholar 

  10. Jalan R, Harrison DJ, Redhead DN, Hayes PC (1996) Transjugular intrahepatic portosystemic stent-shunt (TIPSS) occlusion and the role of primary biliary fistulae. J Hepatol 24:169–176

    Article  PubMed  CAS  Google Scholar 

  11. Nishimine K, Saxon RR, Kichikawa K, Mendel-Hartvig J, Timmermans HA, Shim HJ, Uchida BT, Barton RE, Keller FS, Rösch J (1995) Improved transjugular intrahepatic portosystemic shunt patency with PTFE covered stent-grafts: Experimental results in the swine. Radiology 196:341–347

    PubMed  CAS  Google Scholar 

  12. Haskal ZJ, Rees CR, Ring EJ, Saxon R, Sacks D, and the members of the Technology Assesment Committee of the SCVIR (1997) Reporting standards for transjugular intrahepatic portosystemic shunts. J Vase Interv Radiol 8:289–297

    Article  CAS  Google Scholar 

  13. Cohen CS, Young HY, Ball DS (1996) Stent graft as the treatment for TIPS biliary fistula. J Vase Interv Radiol 7:665–668

    Article  CAS  Google Scholar 

  14. Tanihata H, Saxon RR, Kubota Y, Pavcnik D, Uchida BT, Rösch J, Keller FS, Yamada R, Sato M (1997) TIPSS with silicone covered Wallstents: Results in a swine model. Radiology 205:181–184

    PubMed  CAS  Google Scholar 

  15. Haskal Z, Davis A, McAllister A, Fürth EE (1997) PTFE encapsulated endovascular stent-graft for transjugular intrahepatic portosystemic shunts: Experimental evaluation. Radiology 205:682–688

    PubMed  CAS  Google Scholar 

  16. Benson RW, Payne DD, DeWeese JA (1975) Evaluation of prosthetic grafts of different porosity for arterial reconstruction. Am J Surg 129:665–669

    Article  PubMed  CAS  Google Scholar 

  17. Osborne MP, Murray-Lyon IM, Reynolds K (1979) Dacron bypass grafting in the relief of obstructive jaundice. Lancet 1:1323–1325

    Article  PubMed  CAS  Google Scholar 

  18. Goldman M, McCollum CN, Hawker RJ, Drolc Z, Slaney G (1982) Dacron arterial grafts: The influence of porosity, velour, and maturity on thrombogenicity. Surgery 92:947–952

    PubMed  CAS  Google Scholar 

  19. Edwards RL, Silver J, Rickles FR (1993) Human tumor procoagulants. Registry of the Subcommittee on Hemostasis and Malignancy of the Scientific and Standardization Committee, International Society on Thrombosis and Hemostasis. Thromb Haemost 69:205–213

    PubMed  CAS  Google Scholar 

  20. Pineo GF, Brain MC, Gallus AS, Hirsh J, Hatten MW, Regoeczi E (1974) Tumors, mucus production, and hypercoagulability. Ann N Y Acad Sei 230:262–270

    Article  CAS  Google Scholar 

  21. Reuben A (1984) Biliary proteins. Hepatology 4:46S-50S

    Article  PubMed  CAS  Google Scholar 

  22. Calmus Y, Podevin P, Robert A, Poupon R (1994) Differential effects of chenodeoxycholic and ursodeoxycholic acids on expression of pro-coagulant effectivity by human monocytes. J Hepatol 20:466–472

    Article  PubMed  CAS  Google Scholar 

  23. Violi F, Ferro D, Basili S, Lionetti R, Rossi E, Merli M, Riggio O, Bezzi M, Capocaccia L (1997) Ongoing prothrombotic state in the portal circulation of cirrhotic patients. Thromb Haemost 77:44–47

    PubMed  CAS  Google Scholar 

  24. LaBerge JM, Ring EJ, Gordon RL, Lake JR, Doherty MM, Somberg KA, Roberts JP, Ascher NL (1993) Creation of transjugular portosystemic shunts with the Wallstent endoprothesis: Results in 100 patients. Radiology 187:413–420

    PubMed  CAS  Google Scholar 

  25. Teng GH, Bettmann MA, Hoopes PJ, Wagner RJ, Park BH, Yang L, Baxter BR (1998) Transjugular intrahepatic portosystemic shunt: Effect of bile leak on smooth muscle cell proliferation. Radiology 208:799–805

    PubMed  CAS  Google Scholar 

  26. Ferral H, Alcantara-Pereza A, Kimura Y, Castaüeda-Züniga WR (1998) Creation of transjugular intrahepatic portosystemic shunts with use of the Cragg Endopro Sytem 1. J Vase Interv Radiol 9:283–287

    Article  CAS  Google Scholar 

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Cejna, M., Thurnher, S., Pidlich, J. et al. Primary implantation of polyester-covered stent-grafts for transjugular intrahepatic portosystemic stent shunts (TIPSS): A pilot study. Cardiovasc Intervent Radiol 22, 305–310 (1999). https://doi.org/10.1007/s002709900393

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