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A pilot trial of body weight reduction for nonalcoholic fatty liver disease with a home-based lifestyle modification intervention delivered in collaboration with interdisciplinary medical staff

  • Original Article—Liver, Pancreas, and Biliary Tract
  • Published:
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Abstract

Background

Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of the metabolic syndrome. The aim of this study was to evaluate a 6-month home-based lifestyle modification intervention delivered in collaboration with physicians, hygienists, registered dietitians, and nurses.

Methods

Outpatients with NAFLD diagnosed by abdominal ultrasonography were eligible for this study. Abdominal computed tomography (CT) scan evaluated liver fat deposition by the liver–spleen ratio (L/S ratio) and visceral fat accumulation as the visceral fat area (VFA; cm2). During the 6-month home-based lifestyle modification intervention, each patient was examined by physicians, nurses, hygienists, and registered dietitians, who provided individualized advice to the patients. Patients recorded their daily weight for self-control of weight with recommended diet and exercise regimens.

Results

Sixty-seven NAFLD patients were enrolled in this study and 22 patients (32.8%) completed the 6-month intervention. Nineteen of the 22 patients achieved significant improvements in body weight, body mass index (BMI), waist circumference, VFA, L/S ratio, and systolic blood pressure, with improved laboratory data. Overall, 39 patients withdrew from the intervention. The mean age of the patients who withdrew was 50.0 ± 11.0 years, which was significantly younger than that of the patients who were followed up (60.1 ± 10.1 years; P < 0.01).

Conclusions

The reduction in body weight achieved by NAFLD patients during the 6-month intervention was associated with improved fat deposition and liver function. This intervention offers a practical approach for treating a large number of NAFLD patients with lifestyle modification therapy.

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Acknowledgments

The authors would like to thank the medical staff at Eguchi Hospital; Ms. Yukie Watanabe, Chieko Ogawa, and Reiko Sonoda for their assistance, and Professor Kyuichi Tanikawa (International Institute for Liver Research) for his excellent advice.

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Authors and Affiliations

  1. Department of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan

    Noriko Oza, Yuichiro Eguchi, Toshihiko Mizuta, Eriko Ishibashi, Yoichiro Kitajima, Hirokazu Takahashi, Yasunori Kawaguchi, Ryuichi Iwakiri, Iwata Ozaki & Kazuma Fujimoto

  2. Clinical Gastroenterology, Eguchi Hospital, Mikazuki, Ogi, Saga, Japan

    Eriko Ishibashi, Yoichiro Kitajima, Hiroko Horie, Michiko Ushirogawa, Takeko Tsuzura, Shunya Nakashita, Yasutomo Oda, Takahisa Eguchi & Naofumi Ono

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  1. Noriko Oza
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  2. Yuichiro Eguchi
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  3. Toshihiko Mizuta
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  4. Eriko Ishibashi
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  11. Yasunori Kawaguchi
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  12. Yasutomo Oda
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  13. Ryuichi Iwakiri
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  14. Iwata Ozaki
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  15. Takahisa Eguchi
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  16. Naofumi Ono
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  17. Kazuma Fujimoto
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Corresponding author

Correspondence to Yuichiro Eguchi.

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Oza, N., Eguchi, Y., Mizuta, T. et al. A pilot trial of body weight reduction for nonalcoholic fatty liver disease with a home-based lifestyle modification intervention delivered in collaboration with interdisciplinary medical staff. J Gastroenterol 44, 1203–1208 (2009). https://doi.org/10.1007/s00535-009-0115-x

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  • DOI: https://doi.org/10.1007/s00535-009-0115-x

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