Abstract
Background
Despite the widespread use of endoscopic mucosal resection (EMR) in patients with early gastric cancer (EGC), its longterm outcomes have not been fully evaluated. Our aim was to evaluate longterm survival after complete EMR for EGC.
Methods
From patients who underwent EMR between 1978 and 1996 at our center, we enrolled 131 patients with differentiated mucosal EGCs less than 2 cm (without ulcerative change) that had been completely removed by EMR. The vital status of the patients at the end of December 1998 was confirmed by the hospital cancer registry, which is linked to the Osaka Cancer Registry.
Results
A total of 124 patients (95%) were completely followed-up. Two patients (1.5%) died of gastric cancer and 26 died of other causes during the mean observation period of 58 months. The overall 5- and 10-year survival rates were 84% and 64%, respectively. The disease-specific 5- and 10-year survival rates were 99% and 99%.
Conclusion
En bloc EMR ensured an excellent prognosis, and should be the first choice of treatment in patients with small differentiated mucosal EGC. Careful histological examination and longterm endoscopic surveillance are important.
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References
SM Everett AT Axon (1997) ArticleTitleEarly gastric cancer in Europe Gut 41 142–50 Occurrence Handle9301490 Occurrence Handle1:STN:280:DyaK2svkslSguw%3D%3D Occurrence Handle10.1136/gut.41.2.142
N Tsuji S Ishiguro N Suzuki (1999) ArticleTitleRisk factors for lymph node metastasis of intramucosal gastric cancer: a case-control study Gastroenterol Endosc 41 1059–65
M Nishi S Ishihara T Nakajima K Ohta S Ohyama H Ohta (1995) ArticleTitleChronological changes of characteristics of early gastric cancer and therapy: experience in the Cancer Institute Hospital of Tokyo, 1950–1994 J Cancer Res Clin Oncol 121 535–41 Occurrence Handle7559733 Occurrence Handle1:STN:280:DyaK28%2FjsVSjtw%3D%3D Occurrence Handle10.1007/BF01197766
T Nakajima (2002) ArticleTitleGastric cancer treatment guidelines in Japan Gastric Cancer 5 1–5 Occurrence Handle12021853 Occurrence Handle10.1007/s101200200000
H Tsukuma A Oshima H Narahara T Morii (2000) ArticleTitleNatural history of early gastric cancer: a non-concurrent, long term, follow up study Gut 47 618–21 Occurrence Handle11034575 Occurrence Handle1:STN:280:DC%2BD3M%2FjvVSgtw%3D%3D Occurrence Handle10.1136/gut.47.5.618
InstitutionalAuthorNameJapanese Gastric Cancer Association (1998) ArticleTitleJapanese classification of gastric carcinoma, 2nd English edition Gastric Cancer 1 10–24 Occurrence Handle11957040 Occurrence Handle10.1007/PL00011681
M Tada M Karita H Yanai T Takemoto (1988) ArticleTitleEndoscopic therapy of early gastric cancer by strip biopsy Gan To Kagaku Ryoho (Jpn J Cancer Chemother) 15 1460–5 Occurrence Handle1:STN:280:DyaL1c3ltFSmtg%3D%3D
DM Parkin SL Whelan J Ferlay L Teppo DB Thomas (Eds) (2002) Cancer incidence in five continents, vol VIII. IARC Scientific Publications No. 155 IARC Lyon
H Itoh Y Oohata K Nakamura T Nagata R Mibu F Nakayama (1989) ArticleTitleComplete 10-year postgastrectomy follow-up of early gastric cancer Am J Surg 158 14–6 Occurrence Handle2742043 Occurrence Handle1:STN:280:DyaL1MzgtV2muw%3D%3D Occurrence Handle10.1016/0002-9610(89)90305-X
SM Everett AT Axon (1998) ArticleTitleEarly gastric cancer: disease or pseudo-disease? Lancet 351 1350–2 Occurrence Handle9643813 Occurrence Handle1:STN:280:DyaK1czgsF2ltA%3D%3D Occurrence Handle10.1016/S0140-6736(98)04365-7
D Brandt Y Muramatsu K Ushio Y Mizuguchi M Itabashi S Yoshida et al. (1989) ArticleTitleSynchronous early gastric cancer Radiology 173 649–52 Occurrence Handle2813767 Occurrence Handle1:STN:280:DyaK3c%2FkslKntA%3D%3D
Y Kodera Y Yamamura A Torii K Uesaka T Hirai K Yasui et al. (1995) ArticleTitleIncidence, diagnosis and significance of multiple gastric cancer Br J Surg 82 1540–3 Occurrence Handle8535813 Occurrence Handle1:STN:280:DyaK287jsl2ltA%3D%3D
D Marrano G Viti W Grigioni A Marra (1987) ArticleTitleSynchronous and metachronous cancer of the stomach Eur J Surg Oncol 13 493–8 Occurrence Handle3691822 Occurrence Handle1:STN:280:DyaL1c%2FotlKnug%3D%3D
T Mita T Shimoda (2001) ArticleTitleRisk factors for lymph node metastasis of submucosal invasive differentiated type gastric carcinoma: clinical significance of histological heterogeneity J Gastroenterol 36 661–8 Occurrence Handle11686475 Occurrence Handle1:STN:280:DC%2BD3MnhtFOmtw%3D%3D Occurrence Handle10.1007/s005350170028
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Uedo, N., Iishi, H., Tatsuta, M. et al. Longterm outcomes after endoscopic mucosal resection for early gastric cancer. Gastric Cancer 9, 88–92 (2006). https://doi.org/10.1007/s10120-005-0357-0
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DOI: https://doi.org/10.1007/s10120-005-0357-0