Skip to main content

Advertisement

SpringerLink
Log in

The effect of aspirin and high fibre diet on colorectal carcinoma: a comparative experimental study

  • Published:
Techniques in Coloproctology Aims and scope Submit manuscript

Abstract

Background

The aim of this study is to assess the role of high fibre diet and aspirin on dimethylhydrazine (DMH)-induced colorectal cancer in rats.

Materials and methods

Colorectal tumours were induced with DMH. The animals were randomly divided into five groups (15 rats each): I, controls; II, rats receiving only the carcinogen; III, rats receiving the carcinogen and high fibre diet; IVA, rats receiving the carcinogen plus low dose aspirin; IVB, rats receiving the carcinogen plus high dose aspirin.

Results

Adenocarcinomas were detected in 100% of the rats in group II, 47% of the rats in group III (χ 2, p<0.05), 100% of the rats in group IVA, but the incidence was reduced to 50% in the rats of group IVB (p<0.05).

Conclusions

These data indicate that high fibre diet and aspirin suppress experimental colon carcinogenesis and the protective effect of aspirin is dose related.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. 1st Surgical Department, Aristotle University, Thessaloniki, Greece

    S. Miliaras & D. Kiskinis

  2. Department of Histology, Aristotle University, Thessaloniki, Greece

    D. Miliaras

  3. Department of Pathology, Aristotle University, Thessaloniki, Greece

    E. Vrettou

  4. Department of Pediatric Surgery, Aristotle University, Thessaloniki, Greece

    A. Zavitsanakis

  5. Kimonos Voga str 37, 54643, Thessaloniki, Greece

    S. Miliaras

Authors
  1. S. Miliaras
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Miliaras
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Vrettou
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Zavitsanakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. Kiskinis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Miliaras.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miliaras, S., Miliaras, D., Vrettou, E. et al. The effect of aspirin and high fibre diet on colorectal carcinoma: a comparative experimental study. Tech Coloproctol 8 (Suppl 1), s59–s61 (2004). https://doi.org/10.1007/s10151-004-0113-1

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10151-004-0113-1

Key words

Search

Navigation