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Anti-Inflammation Role for Mesenchymal Stem Cells Transplantation in Myocardial Infarction

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Abstract

The aim of the present study was to investigate the role of anti-inflammation for MSCs transplantation in rat models of myocardial infarction. Rats with AMI induced by occlusion of the left coronary artery were randomized to MSCs transplantation group, MI group and sham operated group. The effects of MSCs transplantation on cardiac inflammation and left ventricular remodeling in non-infarcted zone were observed after 4 weeks of MI. We found that MSC transplantation (1) decreased protein production and gene expression of inflammation cytokines TNF-α, IL-1β and IL-6, (2) inhibited deposition of type I and III collagen, as well as gene and protein expression of MMP-1 and TIMP-1, (3) attenuated LV cavitary dilation and transmural infarct thinning, thus prevent myocardial remodeling after myocardial infarction, and (4) increased EF, FS, LVESP and dp/dtmax (P < 0.01), decreased LVDd, LVEDV, LVEDP (P < 0.05). Anti-inflammation role for MSCs transplantation might partly account for the cardiac protective effect in ischemic heart disease.

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Acknowledgements

We thank Jun Cai (Department of Cardiology, Chaoyang Hospital, Peking), Xi Wang, Ping Hu, Yanhong Tang and Hong-gang Chu (Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan, China) for great assistance. This project was supported by department of health of Hubei province (JX3B48), department of education of Hubei province for excellent youth science and tech group(No T200606), department of technology of Hubei province (2005AA301C38-2) and Xianning college (KY0565).

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Authors and Affiliations

  1. Department of Cardiology, Renmin Hospital of Wuhan University school of medicine, 238 JieFang Road, Wuchang, Wuhan, 430060, People’s Republic of China

    Jun Guo, Guo-sheng Lin & Ming-yan Hu

  2. Cardiovascular Research Institute, Xianning College, Xianning, Hubei, People’s Republic of China

    Cui-yu Bao

  3. Department of Dermatology, First hospital of Wuhan, Wuhan, Hubei, People’s Republic of China

    Zhi-min Hu

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  1. Jun Guo
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Correspondence to Guo-sheng Lin.

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Guo, J., Lin, Gs., Bao, Cy. et al. Anti-Inflammation Role for Mesenchymal Stem Cells Transplantation in Myocardial Infarction. Inflammation 30, 97–104 (2007). https://doi.org/10.1007/s10753-007-9025-3

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  • DOI: https://doi.org/10.1007/s10753-007-9025-3

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