Abstract
Purpose
This study uses linked cycles of assisted reproductive technology (ART) to examine cumulative live birth rates, birthweight, and length of gestation by diagnostic category.
Methods
We studied 145,660 women with 235,985 ART cycles reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System during 2004–2010. ART cycles were linked to individual women by name, date of birth, social security number, partner’s name, and sequence of ART treatments. The study population included the first four autologous oocyte cycles for women with a single diagnosis of male factor, endometriosis, ovulation disorders, diminished ovarian reserve, or unexplained infertility. Live birth rates were calculated per cycle, per cycle number (1–4), and cumulatively. Birthweight and length of gestation were calculated for singleton births.
Results
Within each diagnosis, live birth rates were highest in the first cycle and declined with successive cycles. Women with diminished ovarian reserve had the lowest live birth rate (cumulative rate of 28.3 %); the live birth rate for the other diagnoses were very similar (cumulative rates from 62.1 % to 65.7 %). Singleton birthweights and lengths of gestation did not differ substantially across diagnoses, ranging from 3,112 to 3,286 g and 265 to 270 days, respectively. These outcomes were comparable with national averages for singleton births in the United States (3,296 g and 271 days).
Conclusion
Women with the diagnosis of diminished ovarian reserve had substantially lower live birth rates. However, singleton birthweights and lengths of gestation outcomes were similar across all other diagnoses.
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Acknowledgements
SART wishes to thank all of its members for providing clinical information to the SART CORS database for use by patients and researchers. Without the efforts of our members, this research would not have been possible.
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Capsule Cumulave live birth rate after 4 cycles of ART varied with infertility diagnosis while length of gestation and birthweight did not.
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Stern, J.E., Brown, M.B., Wantman, E. et al. Live birth rates and birth outcomes by diagnosis using linked cycles from the SART CORS database. J Assist Reprod Genet 30, 1445–1450 (2013). https://doi.org/10.1007/s10815-013-0092-0
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DOI: https://doi.org/10.1007/s10815-013-0092-0