Biochemical and Biophysical Research Communications
Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor
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Fibrin-based delivery strategies for acute and chronic wound healing
2018, Advanced Drug Delivery ReviewsCitation Excerpt :Basic fibroblast growth factor (bFGF; FGF-2) [17,61], vascular endothelial growth factor 165 (VEGF165) [18], transforming growth factor-β1 (TGF-β1) [62], platelet-derived growth factor (PDGF) [63], insulin-like growth factor 1 (IGF-1) [63,64] and interleukin 1β (IL-1β) [65] can all be found within a natural fibrin clot. Moreover, circulating growth factors can be sequestered to fibrin via heparin [66,67] which has known affinity for epidermal growth factor (EGF) [68], bFGF [69], PDGF-A and -B [70,71] and VEGF165 [72]. The localized bioactivity and concerted actions of these growth factors in the clot drive neovascularization and subsequent remodeling of the wound bed, which is key to wound healing.
Fibrin matrices: The versatile therapeutic delivery systems
2015, International Journal of Biological MacromoleculesAging skin and wound healing
2013, Clinics in Geriatric MedicineProsthetic material in incisional hernia surgery
2010, Cirugia EspanolaClinical use of colony-stimulating factor-1 in ovulation induction for poor responders
2008, Fertility and SterilityFibroblast Differentiation in Wound Healing and Fibrosis
2007, International Review of CytologyCitation Excerpt :The macrophage is a central figure in chronic inflammation because of the great number of biologically active products it can produce (Vangelista et al., 1991). Growth factors the macrophage is known to synthesize and secrete include PDGF (Zhuo et al., 1998), FGF‐2 (Baird et al., 1985), and TGFβ1 (Associan et al., 1987). Compelling evidence for the role of macrophages as mediators of injury has been provided by renal studies in which macrophage infiltration was reduced by X‐ray irradiation (Diamond and Pesek‐Diamond, 1991) and antimacrophage serum (Matsumoto and Hatane, 1989).
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