EFfects of two methylxanthines, pentoxifylline and propentofylline, on arachidonic acid metabolism in platelets stimulated by thrombin
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Impact of pentoxifylline on platelet function profiles in patients with type 2 diabetes mellitus and coronary artery disease on dual antiplatelet therapy with aspirin and clopidogrel
2011, JACC: Cardiovascular InterventionsCitation Excerpt :Pentoxifylline is a PDE inhibitor currently recommended for the treatment of relief of peripheral vascular disease symptoms (23). Ex vivo and in vitro investigations have also demonstrated the antiplatelet properties of this compound (12,25–30). However, at difference of the PDE inhibitor cilostazol, to date there are no studies that have assessed the impact of pentoxifylline on platelet function profiles in patients receiving DAPT.
Effect of propentofylline on cerebral blood flow in a gerbil focal cerebral ischemia
2001, Journal of the Neurological SciencesLazaroid and pentoxifylline suppress sepsis-induced increases in renal vascular resistance via altered arachidonic acid metabolism
2000, Journal of Surgical ResearchEffect of pentoxifylline on tissue injury and platelet-activating factor production during ischemia-reperfusion injury
1995, Journal of Vascular SurgeryPentoxifylline inhibits tumor necrosis factor-α-mediated cytotoxicity and cytostasis in L929 murine fibrosarcoma cells
1994, International Journal of ImmunopharmacologyActivators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells
1994, International Journal of Radiation Oncology, Biology, Physics
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