Research paperEffects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats☆
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Cited by (47)
Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness
2014, Redox BiologyCitation Excerpt :Alcohol metabolism by Cyp2e1 may be contributing to alcohol-induced effects on the intestine. It is well-established that: (1) Cyp2e1 is expressed in Caco-2 cells as well as in both the small intestine and colon tissue in rodents and humans [36–38]; (2) Cyp2e1 protein is induced in intestinal tissue by chronic alcohol feeding in rodents and humans[36,37,39,40] mainly through post-translational mechanisms rather than mRNA expression [41]; (3) Cyp2e1 is one of the most highly expressed of the CYP450 isoforms in the human intestine [38,42]; and (4) Cyp2e1 metabolism of alcohol produces oxidative stress products [24,36,43] that can contribute to alcohol-induced tissue damage including reactive oxygen species/reactive nitrogen species (ROS/RNS) that could mediate disruption of intestinal epithelial permeability directly [23,26–28]. Oxidative stress also promotes cell signaling, cellular damage, and changes to proteins regulating permeability including tight junction proteins [23,27,28].
Expression of selected cytochrome P450 isoforms and of cooperating enzymes in colorectal tissues in selected pathological conditions
2014, Pathology Research and PracticeCitation Excerpt :CYP2E1 is one of two forms of CYP, which in our studies manifested a much lower expression in the small intestine than in liver. This is consistent with an earlier report in which CYP2E1 showed high expression in the perivenous part of the liver lobule and only low concentrations in the small intestine [40]. Other reports related to intestinal expression of CYP2E1 are contradictory.
CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis
2013, Free Radical Biology and MedicineCitation Excerpt :However, our results simply indicate greater elevation of iNOS and 3-NT levels in the WT-EtOH than in the corresponding Cyp2e1-null mice. Taken together, intestinal CYP2E1, induced by alcohol exposure possibly through protein stabilization [36,39,40], plays a central role in promoting binge alcohol-induced nitroxidative stress, gut leakiness, and bacterial translocation, contributing to elevated levels of serum endotoxin and hepatic cytokines, which prime the liver to more severe injury through oxidative stress-mediated events [11,30,31]. Increased hepatic cytokine levels were also implicated in the development of hepatic steatosis, as recently reported in an acute binge ethanol model [41].
Alcohol and the Gastrointestinal Tract
2005, Comprehensive Handbook of Alcohol Related Pathology
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This work was supported, in part, by NIAAA R01088645(T.M.B).