Elsevier

Biological Psychiatry

Volume 32, Issue 9, 1 November 1992, Pages 803-811
Biological Psychiatry

The prevalence of autoantibodies among right and left handed schizophrenic patients and control subjects☆

https://doi.org/10.1016/0006-3223(92)90083-CGet rights and content

Abstract

Sera from schizophrenic patients (n = 186) and healthy control subjects (n = 346) were tested for the presence of seven common autoantibodies by standard immunological methods. The association between handedness and autoantibodies was tested in a multiway contingency table using a log-linear model. For men, but not women, nondextrals (patients and controls) were twice as likely to test positive for autoantibodies than dextrals (p = 0.0002). Although more women (33%) than men (24%) tested positive for autoantibodies, handedness was not a distinguishing factor among women. These data suggest that sinistrality and gender are associated with autoantibodies in a subgroup of schizophrenic patients and healthy control subjects.

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    ☆

    K.N.R.C. was supported in part by an NIMH Training Grant (MH 16804-10), RG is supported in part by an NIMH Research Scientist Development Award (MH 00710) and by a NARSAD Established Investigator Award. The work is also supported in part by an NIMH grant (MH 41883) to RG and BSR.

    1

    The authors acknowledge Rosemarie Peria, M.S. for project coordination; Wendy Solomon M.P.M., and Colin Bachert B.S. for data management.

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