The interaction of macrophages and bacteria: Escherichia coli species, bacterial lipopolysaccharide, and lipid A differ in their ability to induce tumoricidal activity and the secretion of reactive nitrogen intermediates in macrophages☆
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The study was supported by the Swiss National Science Foundation (Grant 31.25717.88) and the Swiss Cancer League. Part of this work was done in fulfillment of the requirements for the M.D. degree of R.G. at the University of Zurich, Zurich, Switzerland.
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Abbreviations used: BMMø, bone marrow-derived mononuclear phagocytes; FCS, fetal calf serum; IFN, Interferon; IMDM, Iscove's modified Dulbecco medium; KDO, 2-keto-3-deoxyoctulosonic acid; LPS, lipopolysaccharide; NMMA, NG-monomethyl-l-arginine; NO, nitric oxide; NO−2, nitrite; RNI, reactive nitrogen intermediates.
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