Studies of the reaction of acetaldehyde with deoxynucleosides
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Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA
2021, DNA RepairCitation Excerpt :Imines can be irreversibly converted to the corresponding alkylamine adduct by hydride (H:–) reducing agents, such as sodium cyanoborohydride (NaBH3CN), sodium borohydride, or sodium triacetoxyborane (Scheme 2B) [157,166–173]. Biological agents such as glutathione, NAD(P)H, and ascorbate also have the potential to reduce some nucleobase-imine adducts [174–176]. Imines derived from enolizable aldehydes also have the potential to generate enamines [177].
Aldehyde-Induced DNA and Protein Adducts as Biomarker Tools for Alcohol Use Disorder
2018, Trends in Molecular MedicineCitation Excerpt :Several aldehydes, including acetaldehyde and malondialdehyde (MDA), can also react with DNA or protein together to generate hybrid adducts, yielding a product such as a MDA-acetaldehyde (MAA) adduct [16]. Aldehydes form DNA adducts preferentially at the deoxyguanosine amino group and less frequently at deoxyadenosine and deoxycytidine amino groups [76]. By causing DNA damage, aldehyde-induced DNA adducts can promote carcinogenesis through transversion.
Acetaldehyde: A Reactive Metabolite
2016, Neuropathology of Drug Addictions and Substance MisuseAcetaldehyde: A Reactive Metabolite
2016, Neuropathology of Drug Addictions and Substance Misuse Volume 1: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and OpioidsAlcohol and Aldehyde Dehydrogenases: Molecular Aspects
2016, Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition SeriesHypersensitivities for acetaldehyde and other agents among cancer cells null for clinically relevant fanconi anemia genes
2014, American Journal of Pathology
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