Short communicationQuinine inhibits release of tumor necrosis factor, apoptosis, necrosis and mortality in a murine model of septic liver failure
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Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
2019, Biomedicine and PharmacotherapyCitation Excerpt :Several researches involving different experimental models have reported the effects of RA on the liver. LPS) and DGalN-induced liver failure is a well-established experimental model [65–69] which capitalizes on the ability of D-GalN, a transcriptional inhibitor, to potentiate the toxic effects of LPS in producing typical hepatic necrosis and apoptosis followed by fulminant hepatitis [70,71]. LPS activates KC which then secrete various cytokines such as interleukin 1 (IL-1), interleukin 6 (IL-6), and TNF-α [68].
Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria
2011, International Journal for ParasitologyCitation Excerpt :Brain mRNA expression of both these chemokines was significantly reduced on days 6 and 11 p.i. following quinine treatment (Fig. 6). Quinine has previously been proposed to have direct immunomodulatory effects (Bygbjerg et al., 1987; Kremsner et al., 1993; Maruyama et al., 1994; Gantner et al., 1995; Falk et al., 1999). Using a variety of approaches we assessed the ability of quinine to modulate immune function in order to determine whether direct effects of quinine on the immune system could account for protection from CM.
Protective effect of baicalin against Lipopolysaccharide/d-galactosamine-induced liver injury in mice by up-regulation of Heme oxygenase-1
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