Collagenolytic activity in experimental cirrhosis of the liver
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Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation
2013, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :For example, MMP-12 knockout mice accumulate elastin more rapidly than their wild-type counterparts in progressive murine fibrosis models [27], establishing that MMP-12 mediated elastin degradation is occurring even in progressive fibrogenesis. Evidence suggesting that there are changes in the pattern of ECM degradation as well as synthesis in progressive fibrosis was first postulated in the 1970s [52,53]. In these studies collagenase activity was detectable in rat fibrotic liver and decreased with duration of fibrotic injury (in this case CCl4 administration).
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