CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability☆
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2012, PsychoneuroendocrinologyCitation Excerpt :It is known from clinical studies that during IBD, excessive penetration of antigens through a leaky epithelial barrier results in an inappropriate immune stimulation, which leads in turn to chronic gastrointestinal inflammation (Hollander, 1992; Wyatt et al., 1993). For instance, increased epithelial permeability has been shown to play a role in the onset (Hollander et al., 1986; May et al., 1993; Yacyshyn and Meddings, 1995), and relapse, of CD (Wyatt et al., 1993). Support in this direction is also provided from animal studies.
Mucosal immunosuppression and epithelial barrier defects are key events in murine psychosocial stress-induced colitis
2011, Brain, Behavior, and ImmunityCitation Excerpt :A further link between a disrupted barrier function and colonic inflammation comes from animal data showing that bypassing the epithelial barrier by injecting luminal bacterial wall extracts directly into the submucosa initiates a chronic relapsing inflammatory syndrome similar to CD (Yamada et al., 1993). Most importantly, an increased epithelial permeability plays a key role in onset of (Hollander et al., 1986; May et al., 1993; Yacyshyn and Meddings, 1995), as well as the relapses (Wyatt et al., 1993), during CD, and as such was speculated to represent a general mechanism by which the development and perpetuation of IBD is driven. In summary, our findings highlight the vital role of the commensal flora in the initiation of chronic psychosocial stress-induced colonic inflammation.
Identification of Epithelial Gaps in Human Small and Large Intestine by Confocal Endomicroscopy
2007, GastroenterologyCitation Excerpt :These observations therefore have implications for the nature of the intestinal barrier dysfunction in human disease.22–29
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Supported by the Medical Research Council of Canada, the Crohn's and Colitis Foundation of Canada, and the Grawin Foundation.