EditorialAberrant crypt foci and k-ras mutations: Earliest recognized players or innocent bystanders in colon carcinogenesis?
References (39)
Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings
Cancer Lett
(1987)- et al.
Identification and quantification of aberrant crypt foci and microadenomas in the human colon
Hum Pathol
(1991) - et al.
Carcinoembryonic antigen in human colonic aberrant crypt foci
Gastroenterology
(1994) - et al.
Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon
Gastroenterology
(1995) - et al.
Prognostic significance of K-ras mutations in colorectal carcinoma
Gastroenterology
(1993) - et al.
Specificity study to evaluate induction of aberrant crypts in murine colons
Cancer Res
(1988) - et al.
Aberrant crypts: potential preneoplastic lesions in the murine colon
Cancer Res
(1988) - et al.
Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods
Cancer Res
(1989) - et al.
Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions
Cancer Res
(1991) - et al.
Aberrant crypts in human colonic mucosa: putative preneoplastic lesions
J Cell Biochem Suppl
(1992)
Multistage hepatocarcinogenesis
Colonic aberrant crypts in azoxymethane-treated F344 rats have decreased hexosaminidase activity
Am J Pathol
(1990)
Two types of putative preneoplastic lesions identified by hexosaminidase activity in whole-mounts of colons from F344 rats treated with carcinogen
Am J Pathol
(1993)
Dose response and proliferative characteristics of aberrant crypt foci: putative preneoplastic lesions in rat colon
Carcinogenesis
(1991)
Aberrant crypt foci and colon tumors in F344 rats have similar increases in proliferative activity
Int J Cancer
(1994)
Increased cell proliferation of azoxymethane-induced aberrant crypt foci of rat colon
Jpn J Cancer Res
(1994)
Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer
Carcinogenesis
(1992)
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis
Carcinogenesis
(1993)
Sequential analysis of K-ras mutations in aberrant crypt foci and colonic tumors induced by azoxy-methane in Fischer-344 rats on high-risk diet
Carcinogenesis
(1994)
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Clinical relevance of colorectal cancer molecular subtypes
2017, Critical Reviews in Oncology/HematologyCitation Excerpt :Mutations in both genes cluster in codons 12 or 13, and less frequently at codons 59, 61, 117 and 146. KRAS mutations appear even in lesions of low malignant potential, such as aberrant crypt foci lacking dysplasia (Pretlow, 1995), and their frequency increases with polyp size (Vogelstein et al., 1988). A KRAS contributes to disease progression when combined with other genetic alterations in a multistep carcinogenesis model (Shirasawa et al., 1993; Barbie et al., 2009).
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