Gastroenterology

Gastroenterology

Volume 108, Issue 2, February 1995, Pages 600-603
Gastroenterology

Editorial
Aberrant crypt foci and k-ras mutations: Earliest recognized players or innocent bystanders in colon carcinogenesis?

https://doi.org/10.1016/0016-5085(95)90092-6Get rights and content

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      Mutations in both genes cluster in codons 12 or 13, and less frequently at codons 59, 61, 117 and 146. KRAS mutations appear even in lesions of low malignant potential, such as aberrant crypt foci lacking dysplasia (Pretlow, 1995), and their frequency increases with polyp size (Vogelstein et al., 1988). A KRAS contributes to disease progression when combined with other genetic alterations in a multistep carcinogenesis model (Shirasawa et al., 1993; Barbie et al., 2009).

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