Nitric oxide production in experimental alcoholic liver disease in the rat: Role in protection from injury☆
References (62)
- et al.
Endothelium-derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet function
Biochem Pharmacol
(1988) - et al.
Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury
Life Sci
(1989) - et al.
Plasma endothelin levels in chronic ethanol-fed rats: relationship to pathologic liver injury
Life Sci
(1994) - et al.
Decreased prostacyclin production by liver non-parenchymal cells precedes liver injury in experimental alcoholic liver disease
Life Sci
(1994) - et al.
Clearance of gut derived endotoxins by the liver: release and modification of 3H, 14C lipopolysaccharide by isolated rat Kupffer cells
Gastroenterology
(1989) - et al.
Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids
Anal Biochem
(1982) - et al.
Phorbol esters induce nitric oxide synthase activity in rat hepatocytes: antagonism with the induction elicited by lipopolysaccharide
J Biol Chem
(1992) - et al.
Nitric oxide kills hepatocytes by mobilizing mitochondrial calcium
Biochem Biophys Res Commun
(1994) - et al.
Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide
Arch Biochem Biophys
(1991) The delicate balance of nitric oxide and superoxide in liver pathology
Gastroenterology
(1995)
Endotoxin stimulated nitric oxide production increases liver injury and reduces rat liver chemiluminescence during reperfusion
Gastroenterology
Nitric oxide: a novel biological messenger
Cell
Nitric oxide as an antioxidant
Arch Biochem Biophys
Redox signaling-nitrosylation and related target interactions of nitric oxide
Cell
Metabolic alterations produced in the liver by chronic ethanol administration: changes related to energy parameters of the cell
Biochem J
Metabolic alterations produced in the liver by chronic ethanol administration: increased oxidative capacity
Biochem J
The swift increase in alcohol metabolism: time course for increase in hepatic oxygen uptake and the involvement of glycolysis
Biochem J
Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular necrosis
Hepatology
Compensatory mechanisms in response to an elevated hepatic oxygen consumption in chronically ethanol-fed rats
Am J Physiol
Effects of intravenous infusions of ethanol upon estimated hepatic blood flow in man
J Clin Invest
Biochemistry of nitric oxide and its redox-activated forms
Science
Macrophage cytotoxicity: role for l-arginine deaminase activity and amino nitrogen oxidation to nitrite
Science
Vascular endothelial cells synthesize nitric oxide from l-arginine
Nature
Regulation of nitric oxide production by stimulated rat Kupffer cells
Pathobiology
Beef fat prevents alcoholic liver disease in the rat
Alcohol Clin Exp Res
Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report
Hepatology
Ethanol-induced hepatic fibrosis in the rat
Alcohol Clin Exp Res
Protective effects of a novel quinone derivative, (2E)-3-[5-(2,3 dimethoxy-6-methyl-1,4 benzoquinoyl)]-2-nonyl-2-propenoic acid on experimental alcoholic liver injury
J Pharmacol Exp Ther
Pathology of alcoholic liver disease
Semin Liver Dis
Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization
Am J Respir Cell Mol Biol
Pitfalls in histochemical localization studies of NADPH generating enzymes or enzyme systems in rat small intestine
Histochemistry
Cited by (106)
Cirrhosis induced by bile duct ligation alleviates acetic acid intestinal damages in rats: Involvements of nitrergic and opioidergic systems
2018, Pharmacological ReportsCitation Excerpt :Data reported that the activity of cNOS is decreased in cirrhotic human liver and constitutive NO release reduction could promote elevation in intrahepatic portal vascular resistance [38]. Decreased production of NO by nonparenchymal cells may contribute to experimental alcoholic liver disease in the rat [44]. Our data showed that administration of NOS inhibitor block the beneficial effects of cirrhosis on macroscopic colon changes which indicate that overproduction of NO during cirrhosis may result in colon protection against inflammation and injuries.
Leveraging oxidative stress questions in vivo: Implications and limitations
2016, Archives of Biochemistry and Biophysics14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats
2013, Food and Chemical ToxicologyCitation Excerpt :In addition to this, arginine, a substrate for NO has been found to reduce ethanol-induced pathological changes in the liver to a great extent (Nanji et al., 1995). Accumulating evidences have pointed to a direct relationship between GSH and NO, capable of protecting cells from oxidative damage initiated by peroxides or oxidized low density lipoprotein (Moellering et al., 1998; Nanji et al., 1995). From the results obtained so far, it seemed to us that, hepatoprotective function of 14-DAG might linked up with NO mediated preservation of total GSH level.
Ethanol induced adaptive changes in blood for the pathological and toxicological effects of chronic ethanol consumption in humans
2012, Experimental and Toxicologic PathologyEthanol-Induced Hepatotoxicity
2010, Comprehensive Toxicology, Second Edition
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Supported in part by Nitromed. Dr. Stamler is a Pew Scholar in the Biomedical Sciences and the recipient of a Clinical Investigator Award from the National Institues of Health (HL 02582).
The authors thank Dr. Peter Thomas, Robert Miller-Cassman, Vincent Bird, Vincenzo Barletta, and Marianne Slaney for assistance.