Neutrophil adhesion is impaired in a rat model of cholestasis☆
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Circulating neutrophil anti-pathogen dysfunction in cirrhosis
2023, JHEP ReportsDecreased leukocyte recruitment in the mesenteric microcirculation of rats with cirrhosis is partially restored by treatment with peginterferon: An in vivo study
2007, Journal of HepatologyCitation Excerpt :A deficiency in one of the three steps of leukocyte recruitment can result in an inability of neutrophils to infiltrate in a region of inflammation. Impaired leukocyte recruitment has been reported previously in mesenteric venules of portal hypertensive rats [20,21] and in a model of acute cholestasis [22]. These findings support further the hypothesis of an altered anti-bacterial response in the splanchnic circulation.
Reversibility of leukocyte dysfunction in rats with obstructive jaundice
2004, Journal of Surgical ResearchInfiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis
2003, Hepatology Research
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Supported by grants from the Alberta Heritage Foundation for Medical Research (AHFMR), the Canadian Liver Foundation, and the Crohn's and Colitis Foundation. Dr. Kubes is an AHFMR and Medical Research Council scholar, and Dr. Swain is an AHFMR Clinical Investigator. Dr. Kanwar is supported by a Canadian Liver Foundation Studentship and Dr. Tjandra by a Canadian Liver Foundation Summer Studentship.
The authors thank M. Maric and P. Reinhardt for expert technical assistance and Dr. G. May for referral of patient B.L. and for performing the endoscopic retrograde cholangiopancreatography.