Gastroenterology

Gastroenterology

Volume 109, Issue 4, October 1995, Pages 1051-1059
Gastroenterology

Localization of heparin-binding epidermal growth factor-like growth factor in human gastric mucosa

https://doi.org/10.1016/0016-5085(95)90562-6Get rights and content

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      An initial loss of parietal cells is required for induction of metaplasia. Although parietal cells are best known for their secretion of acid into the gastric lumen, they also secrete a number of important mucosal growth factors including transforming growth factor-α, amphiregulin, Heparin-binding EGF-like growth factor (HB-EGF), and Sonic hedgehog (Shh).24–27 The loss of these important factors may induce the transdifferentiation of mature chief cells into SPEM.

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      The process includes cell proliferation, migration and loss of gastrointestinal cells.3 Murayma et al. demonstrated that HB-EGF is synthesized in parietal and gastrin cells, acting in an autocrine or paracrine fashion to regulate proliferation and differentiation of gastric mucosal cells.4 Healing of deep gastric mucosal injury erosions and ulcerations requires epithelial cell migration to accomplish re-epithelialization and epithelial cell proliferation to provide a sufficient number of cells for both re-epithelialization and reconstruction of epithelial glandular structures within the scar.

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    Supported in part by grants-in-aid from the Ministry of Education, Science, and Culture of Japan (grant 06670548 to S.K. and grant 05151047 to S.H. and N.T.) and by a Searl Scientific Research Fellowship (S.H.).

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