Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease☆
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2022, Chemico-Biological InteractionsCitation Excerpt :Likewise, TLR4 activates NF-ĸB and increases the production of inflammatory mediators including TNF-α and IL-6 [7]. Conversely, IL-10 was previously reported to dampen the inflammatory response by curbing pro-inflammatory cytokine production, including TNF-α, through inhibiting antigen expression via MHC class II [45]. Consistent with previous reports, the present results showed that MTX induced a significant increase in the inflammatory response in injured intestine as demonstrated by elevated expression of proinflammatory cytokines including IL-6, TNF-α, and IL-1β and reduced levels of the anti-inflammatory cytokine, IL-10.
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Supported by a grant from the Deutsche Forschungsgemeinschaft (DFG 512/3-4) (to S.S.).
Parts of this work have been presented at the 95th annual meeting of the American Gastroenterological Association, New Orleans, Louisiana.
- 1
Dr. Schreiber's present address is: Fourth Medical Department, Charité (Humboldt University), Berlin, Germany.
- 2
Dr. Raedle's present address is: Department of Medicine, Tabea Hospital, Hamburg, Germany.