Elsevier

Life Sciences

Volume 35, Issue 24, 10 December 1984, Pages 2471-2480
Life Sciences

Folyamines and pancreatic growth induced by caerulein

https://doi.org/10.1016/0024-3205(84)90456-9Get rights and content

Abstract

Activation of polyamine metabolism may be important to initiation of pancreatic cell growth. We are reporting that such activation did occur during pancreatic growth initiation by caerulein, a cholecystokinin analog. Maximal increases in total putrescine (319%), spermidine (63%) and spermine (50%) were observed 12, 96 and 96 hr respectively after the beginning of the caerulein treatment. This time period coincides with pancreatic hypertrophy and hyperplasia as characterized by increased cell mass and DNA content. Rates of pancreatic weight and DNA content increases were significantly correlated with total spermidine and spermine contents. These data suggest that polyamine biosynthesis is closely associated with pancreatic growth.

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    The increases were seen first for putrescine, coincident with observed increases in protein and RNA contents, as well as with initiation of the S phase as evidenced by increase rates of DNA synthesis. These polyamines are needed for pancreatic growth since these growth parameters were reduced following inhibition of ODC by α-difluoromethylornithine (DFMO), a specific inhibitor of the enzyme [132]. The major effect of DFMO was observed on cellularity of the stimulated pancreatic gland as evidenced by its significant reductions in total DNA synthesis and total DNA contents [133].

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