Folyamines and pancreatic growth induced by caerulein
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2020, Advances in Medical SciencesCitation Excerpt :The increases were seen first for putrescine, coincident with observed increases in protein and RNA contents, as well as with initiation of the S phase as evidenced by increase rates of DNA synthesis. These polyamines are needed for pancreatic growth since these growth parameters were reduced following inhibition of ODC by α-difluoromethylornithine (DFMO), a specific inhibitor of the enzyme [132]. The major effect of DFMO was observed on cellularity of the stimulated pancreatic gland as evidenced by its significant reductions in total DNA synthesis and total DNA contents [133].
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