Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis
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Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats
2023, Mutation Research - Genetic Toxicology and Environmental MutagenesisMultidimensional bioresponses in nematodes contribute to the antagonistic toxic interaction between pentachlorophenol and TiO<inf>2</inf> nanoparticles in soil
2022, Journal of Hazardous MaterialsCitation Excerpt :This result indicated that nematodes tended to counteract PCP and nTiO2 via GSH-GST dependent detoxification pathway and GSH-dependent detoxification pathway, respectively. After PCP exposure, the specifically increased GST activity in nematodes could catalyze the conjugation of PCP with GSH to form water-soluble substances for detoxification (Ketterer, 1988); when exposed to nTiO2, stimulated reduction of GSSG to GSH and increased GR activity could strengthen the intracellular reductive defense of nematodes to against nTiO2-induced oxidative stress (Cai et al., 2021). Notably, the GST activity, GSH/GSSG ratio, and GR activity all increased in the PCP-nTiO2 co-exposure group, suggesting a combined consequence under the co-contamination condition.
Germline polymorphisms and the risk of therapy-related myeloid neoplasms
2019, Best Practice and Research: Clinical HaematologyCitation Excerpt :However other studies did not confirm this association [22,23,27,30,31.]]. Another detoxifying enzyme glutathione S-transferase (GST) has been a subject of investigation because GSTs catalyze the conjugation of electrophilic compounds to glutathione and alkylating agents are known substrates of GSTs [32]. GSTT1 and GSTM1 encode two classes of GST enzymes and deletion of these genes is relatively common in the general population [33,34].