Original contributionHepatic amyloidosis in Japan: Histological and morphometric analysis based on amyloid proteins☆
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Liver in Systemic Disease
2023, MacSween's Pathology of the Liver, Eighth EditionThe Liver in Circulatory Disturbances
2019, Clinics in Liver DiseaseCitation Excerpt :Although amyloid commonly presents with symptoms secondary to infiltration of the kidney, heart, and peripheral nervous system, hepatic infiltration with amyloid deposits has been found in approximately 70% of patients with amyloidosis.63,64 Amyloid deposits have been observed within the hepatic parenchyma, stroma, and vasculature.65 Most patients with hepatic involvement of amyloidosis present with hepatomegaly and elevated alkaline phosphatase.66
Synchronous unicentric castleman disease and inflammatory hepatocellular adenoma: A case report
2019, Annals of HepatologyCitation Excerpt :SAA is an acute phase protein, released by hepatocytes during inflammation under the control of several cytokines, in particular IL-6.8 SAA has been involved in hepatic amyloidosis; albeit observed at different frequencies ranging from 4% up to 44%.9’10 More than 50 reports of amyloidosis associated with CD have been published thus far in the medical scientific literature including hepatic amyloid deposition.11-15
The Liver in Systemic Disease
2018, MacSween's Pathology of the LiverHepatic amyloidosis: Morphologic spectrum of histopathological changes in AA and nonAA amyloidosis
2012, Pathology Research and PracticeCitation Excerpt :Although vascular involvement has been reported to be a characteristic feature of primary (AL) amyloidosis and parenchymal involvement of secondary (AA) type in earlier reports, some reports published later proved the opposite [3,13,16]. As in our series, parenchymal (sinusoidal) involvement is a consistent feature of nonAA amyloidosis, whereas vascular involvement is uniformly found in the AA amyloidosis, but the two patterns can coexist in both types of amyloidosis [2,10,21]. AA amyloidosis is associated with underlying diseases, including inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, familial Mediterranean fever (FMF), tuberculosis, and bronchiectasis [20,25].
Systemic Amyloidosis Manifesting as a Rare Cause of Hepatic Failure
2010, Journal of the Chinese Medical Association
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Supported in part by a grant from the Primary Amyloidosis Research Committee, the Ministry of Health and Welfare of Japan.