Cell
ArticleDifferent transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor
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ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer
2022, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :Only several years later it was realized that TNFα was a type II membrane protein, which was processed by an unknown protease to release the mature, soluble TNFα protein [2,3]. By that time it was already known that growth factors such as epidermal growth factor (EGF) [4] or tumor growth factor alpha (TGFα) [5] are synthesized as transmembrane precursors and it was speculated that these proteins were cleaved by an unknown protease to release the active, soluble growth factor [4,5]. Interestingly, around the same time, it was also found that the two types of TNF receptors (TNF-RI and TNF-RII) occurred as truncated, soluble proteins in the supernatant of cells and in some body fluids [6].
From wavy hair to naked proteins: The role of transforming growth factor alpha in health and disease
2014, Seminars in Cell and Developmental BiologyDiscovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates
2012, Journal of Biological ChemistryCitation Excerpt :ADAM substrates exhibit various degrees of glycosylation, whereas distances of glycosylation sites from respective scissile bonds also vary significantly. For example, the cleavage site of TNFα by ADAM17 is only four residues away from a glycosylated residue (46), whereas glycosylation occurs 14 residues away from the TGFα cleavage site (47) and more than 200 residues away from the L-selectin cleavage site (48). In this work, we have investigated the role of glycosylation in the specificity of ADAM-catalyzed reactions using TNFα as a model substrate.
Growth Factors in the Gastrointestinal Tract
2012, Physiology of the Gastrointestinal Tract, Two Volume SetGrowth Factors in the Gastrointestinal Tract
2012, Physiology of the Gastrointestinal Tract
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Present address: Center for Thrombosis and Vascular Research, University of Leuven, Campus Gasthuisberg, B-3000 Leuven, Belgium.