Elsevier

The Lancet

Volume 338, Issue 8776, 9 November 1991, Pages 1175-1176
The Lancet

SHORT REPORTS
Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma

https://doi.org/10.1016/0140-6736(91)92035-ZGet rights and content

Abstract

Although lymphoid tissue is absent in normal gastric mucosa, primary lymphomas arise in the stomach and most of these recapitulate the features of mucosa-associated lymphoid tissue (MALT). Gastric lymphoid tissue is known to be acquired in response to local infection by Helicobacter pylori,and we have confirmed this in 450 patients with H pylori-associated gastritis of whom 125 showed mucosal lymphoid follicles. In 8 patients, B lymphocytes infiltrated epithelium, which is a feature characteristic of MALT. We also examined 110 cases of gastric MALT lymphoma and found H pyloriinfection in 101 of these (92%). We conclude that gastric MALT is acquired in H pylori infection and that this provides the necessary background in which MALT lymphoma might develop.

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