Research paperNicotine inhibits the in vitro production of interleukin 2 and tumour necrosis factor-α by human mononuclear cells
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E-cigarettes compromise the gut barrier and trigger inflammation
2021, iScienceCitation Excerpt :Virtually all changes in the distal colon were reversed by a concomitant co-administration of nicotine. These findings are in keeping with the barrier-tightening effect and anti-inflammatory effect of nicotine that have been demonstrated previously (Eliakim and Karmeli, 2003; Geng et al., 1996; Harries et al., 1982; Lashner et al., 1990; Madretsma et al., 1996; Prytz et al., 1989; Suenaert et al., 2000, 2003; Sykes et al., 2000; Van Dijk et al., 1995; Wang et al., 2012, 2016; Zhang and Petro, 1996). For example, exposure of epithelial monolayers to nicotine and its metabolites at concentrations corresponding to those reported in the blood of smokers significantly improves TJ integrity, and thus decreases epithelial gut permeability (Wang et al., 2012).
Immunotoxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor on Jurkat T cell functions
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2019, Journal of EndodonticsCitation Excerpt :A recent study evaluating the concentration of inflammatory mediators in the dental pulp of smokers and nonsmokers has concluded that smoking compromises the immunoregulatory response of the pulp. There is evidence that nicotine inhibits the production of tumor necrosis factor alpha, IL-2, IL-1, and other inflammatory mediators95. Furthermore, another study on radiographs found a statistically significant association between smoking and AP additional to a delayed bone healing process among smokers96.
Comparison of IL-1β, TNF-α, hBD-2, and hBD-3 Expression in the Dental Pulp of Smokers Versus Nonsmokers
2017, Journal of EndodonticsCitation Excerpt :Our results are in accordance with those of previous studies (19–22). Madretsma et al (20) reported that nicotine caused a significant inhibition of TNF-α production in mononuclear cells isolated from peripheral blood of patients with ulcerative colitis, with effects similar to those of prednisolone. Matsunaga et al (21) reported the effect of nicotine treatment on murine alveolar macrophages after infection with bacteria, which significantly enhanced the replication of bacteria in the macrophages and selectively downregulated the production of TNF-α induced by infection.
Chronic nicotine treatment decreases LPS signaling through NF-κB and TLR-4 modulation in the hippocampus
2017, Neuroscience LettersCitation Excerpt :Furthermore, nicotine increased the expression of BDNF in the hippocampus [40]. Several studies have sought to unveil the molecular mechanisms that are involved in the modulation of inflammatory responses and inflammatory signaling pathways by nicotine [6,23,25,27]. Mouse models of AD indicate that nicotine prevents the activation of NF-κB by inhibiting mitogen-activated protein kinase (MAPK) and downregulates iNOS activity and nitric oxide production.
Smoking Inhibits the Frequency of Bronchovascular Bundle Thickening in Sarcoidosis
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