Full-length reviewVagal afferent modulation of nociception
References (110)
- et al.
Antinociception produced by electrical stimulation of vagal afferents: independence of cervical and subdiaphragmatic branches
Brain Res.
(1991) - et al.
Effects of intrathecal antagonists on the antinociception, hypotension and bradycardia produced by intravenous administration of [d-Ala2]methionine enkephalinamide in the rat
Pharmacol. Biochem. Behav.
(1988) - et al.
Antinociception and cardiovascular responses produced by electrical stimulation of the nucleus tractus solitarius, nucleus reticularis and the caudal medulla
Pain
(1990) - et al.
Raphe magnus inhibition of primate T1–T4 spinothalamic cells with cardiopulmonary visceral input
Pain
(1984) - et al.
Presynaptic localization of opiate receptors in the vagal accessory optic systems; an autoradiographic study
Neuropharmacology
(1978) The nuclei origin of brain stem enkephalin and substance P projections of the rodent nucleus raphe magnus
Neuroscience
(1982)- et al.
Effects of vagal afferent stimulation on cervical spinothalamic tract neurons in monkeys
Pain
(1991) - et al.
Afferent vagal modulation of brain stem somatic reflex activity
Exp. Neurol.
(1970) - et al.
The influence of vagal afferent fiber activity on masticatory reflexes
Exp. Neurol.
(1970) - et al.
Selective labeling of vagal sensory nerve fibers in the lower esophageal sphincter with antero-gradely transported WGA-HRP
Brain Res.
(1987)
Descending modulation of nociceptive transmission by solitary nucleus in cat spinal cord neurons
Pain
Classical conditioning of heart rate in rats using direct vagal stimulation as a US
Pharmacol. Behav.
Inhibition of the feline spinal cord dorsal horn neurons following electrical stimulation of nucleus paragigantocellularis lateralis. A comparison with nucleus raphe magnus
Brain Res.
Speculations on the structure/function relationship for vagal and splanchnic afferent endings supplying the gastrointestinal tract
J. Auton. Nerv. Syst.
Substance P as a baro- and chemoreceptor afferent neurotransmitter: immunocytochemical and neurochemical evidence in the rat
Peptides
Brainstem and spinal pathways mediating descending inhibition from the medullary lateral reticular nucleus in the rat
Brain Res.
Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites
Brain Res.
I. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat
Brain Res.
Characterization of coeruleospinal inhibition of the nociceptive tail-flick reflex in the rat: mediation by spinal α-adrenoreceptors
Brain Res.
A possible interface between autonomie function and pain control: opioid analgesia and the nucleus tractus solitarius
Brain Res.
Evaluation of vagal afferent modulation of the diagastric reflex in cats
Brain Res.
Role of the right vagal nerve trunk in antinociception
Brain Res.
Vagal afferent-mediated inhibition of a nociceptive reflex by intravenous serotonin in the rat. I. Characterization
Brain Res.
The peripheral nociceptive action of intravenous 5-HT requires dual activation of both 5-HT2 and 5-HT3 receptor subtypes in the rat
Brain Res.
Neonatal capsaicin treatment abolishes the nociceptive responses to intravenous 5-HT in the rat
Brain Res.
Characterization of stimulation-produced analgesia from the nucleus tractus solitarius in the rat
Brain Res.
Lateral reticular regions and the descending control of dorsal horn neurons of the cat: selective inhibition by electrical stimulation
Brain Res.
Volume loading hypoalgesia in SHR, WKY and F1 offspring of a SHR×WKY cross
Brain Res.
Medullary substrates mediating antinociception produced by electrical stimulation of the vagus
Brain Res.
Medullary substrates of descending spinal inhibition activated by intravenous administration of [d-Ala2] methionine enkephalinamide in the rat
Brain Res.
[d-Ala2]methionine enkephalinamide (DALA): Characterization of antinociceptive, cardiovascular and autonomic nervous system actions in conscious and pentobarbital-anesthetized rat
Pharmcol. Biochem. Behav.
Interactions between cardiovascular and pain regulatory systems
Neurosci. Biobehav. Rev.
[d-Ala2]methionine enkephalinamide reflexively induces antinociception by activating vagal afferents
Pharmacol. Biochem. Behav.
Antinociception and cardiovascular responses produced by intravenous morphine: the role of vagal afferents
Brain Res.
Evidence that glutamic acid is the neurotransmitter of baroreceptor afferents terminating in the nucleus tractus solitarius (NTS)
J. Auton. Nerv. Syst.
Vagal afferent modulation of a nociceptive reflex in rats: involvement of spinal opioid and monoamine receptors
Brain Res.
Spinal serotonergic and K opioid receptors mediate facilitation of the tail flick reflex produced by vagal afferent stimulation
Pain
Effects of electrical stimulation of vagal afferents on spinothalamic tract cells in the rat
Pain
Pharmacological analysis of analgesia and self-stimulation elicited by electrostimulation of catecholamine nuclei in the rat brain
Brain Res.
Evidence for involvement of separate mechanisms in the production of analgesia by electrical stimulation of the nucleus reticularis paragigantocellularis and nucleus raphe magnus in the rat
Brain Res.
Analgesia produced by electrical stimulation of catecholamine nuclei in the brainstem
Brain Res.
Topographic priniciples in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat
Neuroscience
Involvement of vagal afferents and the caudal medulla in the modulation of a nociceptive reflex in the rat
Vagal afferent inhibition of primate thoracic spinothalamic neurons
J. Neurophysiol.
Vagal afferent inhibition of spinothalamic cell responses to sympathetic afferents and bradykinin in the monkey
Circ. Res.
Descending monoaminergic projections to the spinal cord
Intraspinal course of descending serotonergic pathways innervating the rodent dorsal horn and lamina X
J. Comp. Neurol.
Afferent vagal C fibre innervation of the lungs and airways and its functional significance
Rev. Physiol Biochem. Pharmacol.
Inhibition of nociceptive neuronal responses in the cat's spinal dorsal horn by electrical stimulation and morphine microinjection in the nucleus raphe magnus
Pain
Brainstem control of spinal pain transmission neurons
Ann. Rev. Physiol.
Cited by (270)
Manual therapy on the diaphragm is beneficial in reducing pain and improving shoulder mobility in subjects with rotator cuff injury: A randomized trial
2023, International Journal of Osteopathic MedicinePlacentophagia and the Tao of POEF
2023, Neuroscience and Biobehavioral ReviewsAbdominal Pain
2022, Comprehensive PharmacologyVagus nerve afferent stimulation: Projection into the brain, reflexive physiological, perceptual, and behavioral responses, and clinical relevance
2022, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :The modulatory effects in the brain of norepinephrine and serotonin, along with gamma-aminobutyric acid (GABA) (Ben-Menachem et al., 1995; Marrosu et al., 2003), each play a role in the anti-seizure or anti-depressive effects. Similarly, anti-nociceptive effects of vagal stimulation are, in part, dependent on the activation of opioid receptors as well as the descending noradrenergic and serotonergic systems within the spinal cord, which act on second order nociceptive neurons to produce nociceptive inhibition (Basbaum and Fields, 1978; Randich and Aicher, 1988; Ren et al., 1990; Randich and Gebhart, 1992). Functional imaging studies on iVNS and tVNS, discussed above, have reported activity within brain regions that not only respond to and modulate pain, e.g., insula, anterior cingulate cortex (Apkarian et al., 2005; Bushnell et al., 2013), but also modulate affect and other psychological factors (e.g., attention), each of which can differentially interact with aspects of the pain experience such as pain intensity vs. pain unpleasantness (Bushnell et al., 2013; Frangos and Komisaruk, 2017).