Mutagenicity of benzo[a]pyrene and dibenzopyrenes in the Salmonella typhimurium TM677 and the MCL-5 human cell forward mutation assays
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A look beyond the priority: A systematic review of the genotoxic, mutagenic, and carcinogenic endpoints of non-priority PAHs
2021, Environmental PollutionCitation Excerpt :Thirty-four studies have shown the potential of Db[al]P in genotoxicity events, studied using different approaches, such as computational prediction (Mersch-Sundermann et al., 1992a; 1992c), generation of adducts (Binková et al., 2000; Buters et al., 2002; Cavalieri et al., 2005; Chen et al., 2012; DeMarini et al., 2011; Dreij et al., 2004, 2005; Harper et al., 2015; King et al., 1999; Lagerqvist et al., 2008; Luch et al., 1999; Mahadevan et al., 2005, 2006; Melendez-Colon et al., 1999; Nakatsuru et al., 2004; Nesnow, 1997; Prahalad, 1997; Siddens et al., 2012; Todorovic et al., 2005; Topinka et al., 2008; Wohak et al., 2016; Yoon et al., 2004; Zhang et al., 2011, 2014), comet assay (Mourón et al., 2006; Niziolek-Kierecka et al., 2012), phosphorylation of H2AX (ɣH2AX) (Audebert et al., 2012; Kucab et al., 2019; Niziolek-Kierecka et al., 2012; Zheng et al., 2019), chromosomal damage (Meschini et al., 2010; Mourón et al., 2006) in different experimental models, such as cell culture or mice and rats, and using the chromotest assay in E. coli in the presence of S9 (Mersch-Sundermann et al., 1992b). Db[al]P mutagenicity was positive in all ten studies in both prokaryotic (Salmonella TA98, TA100, TA104, and TM677 strains) (Busby et al., 1995; DeMarini et al., 2011; Devanesan et al., 1990) and eukaryotic (HPRT and tk loci) (Busby et al., 1995; Durant et al., 1996; Kushman et al., 2007; Lagerqvist et al., 2008) models, as well as in transgenic mice with germ cell mutations (Chen et al., 2013; Guttenplan et al., 2012; Leavitt et al., 2008). Db[al]P induced tumor formation (11 studies) in different strains of mice and rats (Amin et al., 1995; Buters et al., 2002; Cavalieri et al., 1989, 1991; Chen et al., 2012, 2013; LaVoie et al., 1993; Madeen et al., 2017; Prahalad, 1997; Shorey et al., 2012; Siddens et al., 2012) (Fig. 6L, Table S14).
Cancer chemoprevention by dietary chlorophylls: A 12,000-animal dose-dose matrix biomarker and tumor study
2012, Food and Chemical ToxicologyCitation Excerpt :The polycyclic aromatic hydrocarbon dibenzo(def,p)chrysene (DBC), formerly known as dibenzo(a,l)pyrene or DBP, can be readily detected on particulate matter from wood charcoal, coal, and fuel–oil combustion (Deraat et al., 1987; Mumford et al., 1987, 1995) in soil and sediment samples (Kozin et al., 1995), in vehicle exhaust condensate (Seidel et al., 2004), and in tobacco smoke condensate (Snook et al., 1977; Hoffmann and Hoffmann, 1998). DBC displays strong in vitro mutagenicity in bacterial and animal cell assays (Busby et al., 1995; Durant et al., 1999), forms multiple DNA adducts in vitro and in vivo (Mahadevan et al., 2005), and may act in vivo through promotional as well as tumor initiation mechanisms (Baird et al., 2005). Comparative studies in rodent models have demonstrated DBC to be the most carcinogenic polycyclic aromatic hydrocarbon tested to date, significantly exceeding the potencies of the well-known carcinogens benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene (Cavalieri et al., 1989, 1991; Higginbotham et al., 1993; LaVoie et al., 1993).
Association between mutation spectra and stable and unstable DNA adduct profiles in Salmonella for benzo[a]pyrene and dibenzo[a,l]pyrene
2011, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisCitation Excerpt :Although DBP did not induce a significant increase in unstable DNA adducts relative to the control (P = 0.78), BP did (P = 0.03). As noted in Section 1, DBP is more carcinogenic in rodents, more mutagenic in forward-mutation assays, and is a more potent DNA-damaging agent than BP [11–20]. However, the relative mutagenic potencies of these PAHs vary in bacterial reverse-mutation assays depending on the strain [21] (Table 2).
Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (±)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1
2007, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisCharacterization of naphtho[1,2-a]pyrene and naphtho[1,2-e]pyrene DNA adducts in C3H10T1/2 fibroblasts
2007, Cancer LettersCitation Excerpt :Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous anthropomorphic environmental pollutants that represent a large class of carcinogenic chemicals. Dibenzo[a,l]pyrene (DB[a,l]P) is a hexacyclic PAH containing a pyrene moiety and a fjord-region that possesses high mutagenic and carcinogenic activities (Fig. 1) [1–5]. DB[a,l]P is the most potent PAH tested and is more potent than benzo[a]pyrene (B[a]P) in mutagenicity and carcinogenicity assays [1–5].