Progression from idiopathic portal hypertension to incomplete septal cirrhosis with liver failure requiring liver transplantation

doi:10.1016/0168-8278(95)80115-4

Journal of Hepatology

Volume 22, Issue 4, April 1995, Pages 495-499

https://doi.org/10.1016/0168-8278(95)80115-4 Get rights and content

Abstract

We report the case of a 30-year-old male patient suffering from what was initially thought to be end-stage cryptogenic cirrhosis with portal hypertension and liver failure, who underwent liver transplantation. Histological examination of the surgical specimen showed incomplete septal cirrhosis. At the age of 17 this patient had presented pancytopenia and splenomegaly, which were treated by splenetomy. The surgeon discovered portal hypertension. Re-examination of the wedge liver biopsy taken at this time revealed features of idiopathic portal hypertension.

This case clearly shows that incomplete septal cirrhosis may be a late manifestation of idiopathic portal hypertension. The presence of sinusoidal dilatation and peliosis as well as early evidence of fibrosis which are already visible on the initial biopsy and are still present on the late specimen, are indirect evidence of a continuous process which ultimately led to incomplete cirrhosis with liver failure.

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Progression from idiopathic portal hypertension to incomplete septal cirrhosis with liver failure requiring liver transplantation

Abstract

Gastroenterology

Gastroenterology

Gastroenterology

Am J Med

What are the major types of hepatic cirrhosis?

Incomplete septal cirrhosis: histopathological aspects

Histopathology

Obliterative portal venopathy of the liver

Arch Pathol Lab Med