Serum hyaluronan as a marker of liver fibrosis in chronic viral hepatitis C: effect of α-interferon therapy
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Investigation of Serum Markers of Hepatic Fibrosis in Equids
2023, Journal of Equine Veterinary ScienceModulation of hyaluronan signaling as a therapeutic target in human disease
2022, Pharmacology and TherapeuticsCitation Excerpt :Dysregulation of HA metabolism is a hallmark of many inflammatory and degenerative diseases. Increased levels of circulating or tissue HA have been found in many lung disorders including asthma, COPD, interstitial lung disease, and pulmonary hypertension (Lauer, Dweik, Garantziotis, & Aronica, 2015; Lennon & Singleton, 2011), as well as inflammatory, fibrotic and degenerative diseases like rheumatoid arthritis (Poole et al., 1990), hepatitis (Guechot et al., 1995; Peters et al., 2013), cirrhosis (Gudowska et al., 2016; Plevris et al., 2000), chronic kidney disease (Stridh, Palm, & Hansell, 2012), atherosclerosis (Fischer, 2019), cardiac remodeling in failure (Hackert et al., 2021), diabetic pancreas (Bogdani et al., 2014), allograft rejection (Cui et al., 2015b; Todd et al., 2014; Wells et al., 1993), virtually every type of solid cancer (Tammi et al., 2008; Toole, 2004; Toole, 2020; Toole et al., 2008), etc. In most, or all these diseases, elevated serum levels of HA have been associated with adverse outcomes and worse prognosis.
The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix
2020, Food and Chemical ToxicologyCitation Excerpt :Elastin-derived peptides are bioactive and act as chemoattractants for monocytes, fibroblasts, and endothelial cells (Duca et al., 2004). HA is a major glycosaminoglycan produced and deposited in liver fibrosis, and its serum level has been used as a biomarker for diagnosing the stages of liver fibrosis in clinical practice (Neuman et al., 2016; Tamaki et al., 1996; Guechot et al., 1995), with higher levels indicating poorer prognoses in patients with chronic liver injury (Peters et al., 2013; Hansen et al., 2019; Korner et al., 1996). Large deposits of HA are seen in fibrotic areas of diseased livers, while no or minimal HA deposition is observed in the normal liver (Yang et al., 2019; Satoh et al., 2000).
Platelet hyaluronidase-2: An enzyme that translocates to the surface upon activation to function in extracellular matrix degradation
2015, BloodCitation Excerpt :This is important because HA is upregulated during inflammation in many tissues, and smooth muscle cells and myofibroblasts are considered to be the major HA-producing cells. High levels of HA deposition have been reported in several inflammatory diseases including asthma, arthritis, and hepatitis.8,9,44,45 In addition, our group has reported an upregulation of HA in the intestines of patients with IBD, a chronic condition characterized by tissue erosion and intestinal bleeding.10,46
The chronic enteropathogenic disease schistosomiasis
2014, International Journal of Infectious DiseasesCitation Excerpt :Hyaluronic acid (HA), a high molecular weight GAG, is an essential ECM component. It is synthesized by HSCs and is degraded by the sinusoidal endothelial cells.78,79 Increased levels are due either to decreased hepatic removal or to increased production by stellate cells, or to both processes.80
Serological markers of fibrosis
2012, Gastroenterologia y Hepatologia