Liver injury related to amoxycillin-clavulanic acid: interlobular bile-duct lesions and extrahepatic manifestations
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Hepatic Injury due to Drugs, Dietary and Herbal Supplements, Chemicals and Toxins
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2017, Clinics in Liver DiseaseCitation Excerpt :A prospective series of amoxicillin/clavulanate hepatotoxicity from Spain reported that age was the most important determinant in the biochemical manifestation of hepatotoxicity; younger age was associated with hepatocellular injury and shorter treatment duration, whereas cholestatic/mixed injury was related to older age and prolonged amoxicillin/clavulanate therapy.8 Typical histologic features were centrilobular cholestasis with a mixed portal inflammatory infiltrate, variable portal edema, and interlobular bile duct injury with bile duct proliferation.6,14 In addition, granulomatous hepatitis has also been reported.13,15
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2013, Clinics in Liver DiseaseCitation Excerpt :A case of granulomatous hepatitis also has been attributed to this combination drug.72 Recovery usually occurs within 1 to 4 months, although fatal outcomes have been reported.69 First-generation and second-generation cephalosporins are rarely associated with DILI, and only a few instances of cholestatic hepatic injury have been reported.1
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