Factors predictive of response to interferon therapy in children with chronic hepatitis B
References (19)
- et al.
Liver cirrhosis associated with chronic hepatitis B virus infection in childhood
J Pediatr
(1986) - et al.
Recombinant alpha-2 interferon treatment in children with chronic hepatitis B
Lancet
(1988) - et al.
Changes of hepatitis B virus (HBV) markers during prolonged recombinant interferon alpha-2A treatment of chronic HBV infection
J Hepatol
(1987) - et al.
Factors affecting clearance of hepatitis B e antigen in hepatitis B surface antigen carrier children
J Pediatr
(1989) - et al.
Childhood hepatocellular carcinoma develops exclusively in hepatitis B surface antigen carriers in three decades in Taiwan
J Hepatol
(1987) - et al.
Primary hepatocellular carcinoma and hepatitis B infection during childhood
Hepatology
(1987) - et al.
Different doses of recombinant interferon alpha in the treatment of chronic hepatitis B patients without antibodies against the human immunodeficiency virus
Hepatogastroenterology
(1988) - et al.
A controlled trial of recombinant interferon alpha in Caucasian children with chronic hepatitis B
Digestion
(1990) - et al.
Prospective, randomized controlled trial of interferon alpha in children with chronic hepatitis B
Hepatology
(1991)
Cited by (28)
Hepatitis B virus infection
2007, Seminars in Fetal and Neonatal MedicineCitation Excerpt :Transient growth suppression in some young children may occur during therapy. In patients with elevated aminotrans-ferase levels, the results of interferon treatment are similar to those in adults, with the rate of HBe seroconversion and normalisation of aminotransferase levels being 20–40% higher in the treatment group than in the control group.41–46 A systematic meta-analysis of the literature has shown a significant benefit of interferon therapy for chronic HBV infection in children.47
Interferon treatment for chronic hepatitis B: Enhanced response in children 5 years old or younger
2004, Journal of PediatricsCitation Excerpt :Pretreatment factors that are reported correlate with a higher likelihood of response to IFN in HBV-infected adults include high pretreatment ALT levels, low HBV-DNA levels, and female sex.9 Similar pretreatment factors have been associated with response to IFN treatment in children.10,11 Our patients had many of these pretreatment factors: a high level of ALT activity at entry, a relatively low HBV-DNA concentration, and absence of cirrhosis.
Treatment of chronic hepatitis B in children
2003, Journal of HepatologyPrognostic factors and early predictability of sustained viral response with peginterferon alfa-2a (40KD)
2002, Journal of HepatologyQuand traiter par l'interféron un enfant atteint d'hépatite chronique B ?
1999, Archives de Pediatrie