Contractile and dilatory action of neuropeptides on isolated human mesenteric blood vessels
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The pig is a better model than the rabbit or rat for studying the pathophysiology of human mesenteric arteries
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2012, Physiology of the Gastrointestinal TractSmooth muscle neurokinin-2 receptors mediate contraction in human saphenous veins
2011, Pharmacological ResearchCitation Excerpt :The wide expression of tachykinins, tachykinin receptors and NEP in the SV suggested that the tachykinin system may have both physiologic and pathophysiologic interests at this richly innervated portion of the vascular system [23], which we further investigated with functional studies. SP is known to induce an endothelium-dependent relaxation in numerous human vascular preparations [3–8,11–13], and endothelial NK1-receptors have been shown to mediate the relaxation of human pulmonary arteries and veins [11,12]. In pre-constricted SV segments from patients undergoing coronary artery bypass surgery, SP produced a relaxation which was markedly attenuated after the removal of the endothelium [32].
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2002, Japanese Journal of Pharmacology
Copyright © 1987 Published by Elsevier Inc.