Other clinical studyAbnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody—negative primary biliary cirrhosis☆
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Cited by (65)
Bile Duct Diseases
2023, MacSween's Pathology of the Liver, Eighth EditionAutoantibodies in Primary Biliary Cholangitis
2022, Clinics in Liver DiseaseCitation Excerpt :It is thought that AMA-negative PBC is a similar disease process to AMA-positive PBC involving abnormal expression of PDC-E2 and/or molecular mimicry of PDC-E2. Tsuneyama and colleagues demonstrated that sera from AMA-negative patients react similarly to sera from AMA-positive patients, with intense staining of the apical region of the bile duct epithelial cells for PDC-E2, suggesting similar disease processes.39 It has been previously proposed that a worse prognosis exists for patients diagnosed with AMA-negative PBC compared with AMA-positive PBC, with reduced transplant-free survival40 and worse bile duct damage around portal areas on histopathology with increased levels of B-cell infiltrates in early phases of bile duct damage.41
Immunologic Responses and the Pathophysiology of Primary Biliary Cholangitis
2022, Clinics in Liver DiseaseAntimitochondrial Antibody–Negative Primary Biliary Cholangitis: Is It Really the Same Disease?
2018, Clinics in Liver DiseaseBile Duct Diseases
2018, MacSween's Pathology of the LiverThe diagnosis of antimitochondrial antibody-negative primary biliary cholangitis
2016, Clinics and Research in Hepatology and Gastroenterology
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Supported by National Institutes of Health, grant no. DK39588, Bethesda, MD.