Other clinical studyPlasma levels of substance p in liver cirrhosis: Relationship to the activation of vasopressor systems and urinary sodium excretion☆
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2012, Gastroenterologia y HepatologiaPathophysiological basis of albumin use in cirrhosis
2011, Annals of HepatologyCitation Excerpt :This is manifested primarily by the development of renal failure. The administration of diuretics, therapeutic paracentesis without albumin12,13 or severe bacterial infections15,33 are associated with renal failure in approximately 15-30% of these patients. Under physiological conditions the regulation of blood pressure and effective arterial blood volume is carried out mainly in the splanchnic and renal vascular compartments.
Relationship Between Activation of the Sympathetic Nervous System and Renal Blood Flow Autoregulation in Cirrhosis
2008, GastroenterologyCitation Excerpt :The reduction in noradrenaline levels was statistically significant, but this was not normalized and was significantly higher than normal and similar to that in patients with diuretic-responsive ascites. These results of the reduction in noradrenaline levels are in keeping with previous studies, which have also shown a similar significant reduction in the levels of systemic noradrenaline at different time points after insertion of a TIPS.26,36–39 This would suggest that a therapeutic TIPS insertion alters the renal sympathetic drive, moving the patients toward a higher renal blood flow by causing an upward and leftward shift with a more pronounced plateau of the renal blood flow/renal perfusion pressure relationship curve.
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Supported by grants from Fondo de Investigaciones Sanitarias and Fundación Ramón Areces. Dr. Fernández-Rodriguez is recipient of grant no. 92/1071 from the Fondo de Investigaciones Sanitarias, Spain.