Long-term effects of cerebellar pathology on cognitive functions☆
References (12)
- et al.
A refined method to relate morphological and functional aspects of aphasia
European Neurology
(1981) - et al.
- et al.
- et al.
Neuropsychologic findings in Friedreich's ataxia
Archives of Neurology
(1984) - et al.
Dementia after surgery for cerebellar stroke: An unrecognized complication of acute hydrocephalus?
Neurology
(1985)
Cited by (99)
Cerebellar Cognitive-Affective Syndrome: A Case Report and Review of Literature
2023, Revista Colombiana de PsiquiatriaMind the gaps: What we don't know about cognitive impairment in essential tremor
2019, Parkinsonism and Related DisordersCitation Excerpt :However, a recent population based study did highlight subtle differences in the two groups; while both groups performed more poorly than controls, the PD group had differentially worse performance on an executive measure (i.e., verbal fluency) than the ET group, and the latter evidenced slower processing speed [26] than the PD group. Given the documented role of the cerebellum in supporting executive functioning [28,29], and the known compromise of the cerebellum in ET [30–34], executive deficits in ET have generally been conceptualized as the result of inefficient cerebellar-cortical networks, particularly those projecting to and from the prefrontal cortex [35–40]. Indeed, deterioration in such networks may well underlie executive dysfunction in patients with ET, particularly those who do not progress to dementia.
Anatomo-functional study of the cerebellum in working memory in children treated for medulloblastoma
2019, Journal of NeuroradiologyCitation Excerpt :Gottwald et al. [16] showed that the right cerebellar hemisphere is engaged in verbal working memory or the phonological loop while left cerebellar hemisphere plays a role in non-verbal or visuospatial working memory. These results are also compatible with those of Scott et al. [17], by Wallesch & Horn [18], by Riva & Giorgi [19], and the study of Botez-Marquard et al. [20]. All of these data allow us to strengthen the participation of the cerebellum in cognitive function, including the role of the left cerebellum in visuospatial working memory.
The role of the cerebellum in cognition: Beyond coordination in the central nervous system
2014, Neurologic ClinicsCitation Excerpt :Many of the subsequent studies in the patients with focal and neurodegenerative disorders of the cerebellum (especially olivopontocerebellar ataxia, Friedreich ataxia, and cerebellar cortical atrophy), have explored the role of the cerebellum in visuospatial procedures and shown the link between right hemisphere deficits of visuospatial organization to left cerebellar hemisphere damage.50,114,115 Even though visuospatial deficits also have been observed in a heterogeneous group of patients with cerebellar disorders,111,115,116 standard neuropsychological tests of visuospatial ability may not provide strong support in the cerebellum’s role in this cognitive domain.117,118 One study has suggested119 that the initial impairment was restricted to patients with atrophy extending into the brainstem, whereas another120 has shown that cerebellar patients would have difficulty in performing any visual task requiring precise timing.
Low scores on the Benton Facial Recognition Test associated with vertebrobasilar insufficiency
2013, Medical HypothesesCitation Excerpt :Furthermore, evidence suggests that the cerebellum is activated by various cognitive tasks [9,10]. Early studies of cognitive deficits in patients with cerebellar lesions reported that visuospatial ability was impaired following cerebellar damage [10,11]. Molinari et al. [10] focused on visuospatial performance in subjects with cerebellar damage and reported that cerebellar disorders were not strictly associated with motor symptoms but had significant effects on cognitive ability, including visuospatial skills.
Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing
2010, CortexCitation Excerpt :This prediction is supported by functional neuroimaging findings that language and spatial functions are lateralized within the cerebellum (see above), and clinical reports that language impairments such as impaired verbal fluency (Akshoomoff et al., 1992; Appollonio et al., 1993; Hassid, 1995; Leggio et al., 1995, 2000; Molinari et al., 1997; Schmahmann and Sherman, 1998; Gasparini et al., 1999; Levisohn et al., 2000; Riva and Giorgi, 2000; Gebhart et al., 2002; Richter et al., 2007b) and agrammatism (Silveri et al., 1994; Zettin et al., 1997; Schmahmann and Sherman, 1998; Marien et al., 2001; Ackermann et al., 2004; Kalashnikova et al., 2005) generally arise following right cerebellar hemisphere lesions. In contrast, visual spatial difficulties are more likely to occur after left cerebellar damage (see Wallesch and Horn, 1990; Fiez et al., 1992; Botez-Marquard et al., 1994; Levisohn et al., 2000; Riva and Giorgi, 2000; Scott et al., 2001; Gebhart et al., 2002; Gottwald et al., 2004; Gross-Tsur et al., 2006; Hokkanen et al., 2006), although these findings are less consistent than the link between the right posterolateral cerebellum and language. The suggestion that language problems are primarily due to motor (articulatory) impairment is not supported by patient studies.
- ☆
This research was supported by the Deutsche Forschungsgemeinschaft, SFB 325.