On the neuropharmacology of thyrotropin releasing hormone (TRH)
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Cited by (216)
The potential role of thyrotropin-releasing hormone in colonic dysmotility induced by water avoidance stress in rats
2018, NeuropeptidesCitation Excerpt :Although much progress has been made in the involvement of these brain–gut peptides in IBS, the mechanism by which they contribute to IBS pathogenesis is not fully understand. Thyrotrophin releasing hormone (TRH) was the first hypothalamic releasing peptide to be discovered (Burgus et al., 1970; Yarbrough, 1979). Based on its actions in regulating of thyrotrophin or thyroid stimulating hormone secretion, it was primarily considered as a physiological regulator of pituitary function (Kamath et al., 2009).
Regulation of the hypothalamic Thyrotropin Releasing Hormone (TRH) neuron by neuronal and peripheral inputs
2010, Frontiers in NeuroendocrinologyCitation Excerpt :The thyroid gland provides an unchanging basal level of thyroid hormone to keep the basic metabolic rate of all cells at a constant level, and provides the overall set point of this endocrine axis. The maintenance of euthyroidism is dependent on TRH regulation of TSH [105,107] as well as by feedback of thyroid hormones, which suppress preproTRH expression and TSH secretion [168,276]. The significance of TRH in the regulation of thyroid axis was demonstrated in humans with a TRH receptor mutation and in mice lacking the TRH gene, which in both cases caused central hypothyroidism [40,275].
Evaluation of the effect of thyrotropin releasing hormone (TRH) on regional cerebral blood flow in spinocerebellar degeneration using 3DSRT
2009, Journal of the Neurological SciencesThe thyrotropin-releasing hormone (TRH)-immune system homeostatic hypothesis
2009, Pharmacology and TherapeuticsRole of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding
2006, Autonomic Neuroscience: Basic and Clinical