Antitumor effect induced by the expression of granulocyte macrophage-colony stimulating factor gene in murine colon carcinoma cells

doi:10.1016/0304-3835(96)04141-9

Cancer Letters

Volume 101, Issue 2, 29 March 1996, Pages 257-261

https://doi.org/10.1016/0304-3835(96)04141-9 Get rights and content

Abstract

Murine colon carcinoma cells which secrete several kinds of cytokine after retroviral transduction with corresponding genes, were examined for their antitumor effects in syngeneic mice. The mice inoculated with granulocyte macrophage colony stimulating factor (GM-CSF) producer cells showed not only prolonged survival but also reduced tumorigenicity. The antitumor effect caused by the expression of interleukin-4 was less than that of GM-CSF, and interleukin-6 producer cells did not show any effects on the survival of the host animals. Histological examination of the GM-CSF-producing tumor revealed predominant infiltration of neutrophils and necrotic change of the tumor. The present study indicates the feasibility of cancer gene therapy with the expression of GM-CSF gene in tumor cells.

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Antitumor effect induced by the expression of granulocyte macrophage-colony stimulating factor gene in murine colon carcinoma cells

Abstract

Cell

J. Urol.

Cell

Cancer gene therapy clinical trials

Cancer Gene Ther.

In vivo gene therapy of human lung cancer using wild-type p53 delivered by retrovirus

J. Natl. Cancer Inst.

Drug sensitivity (‘suicide’) genes for selective cancer chemotherapy

Cancer Gene Ther.

Experimental and clinical studies of cytokine gene-modified tumor cells

Hum. Gene Ther.

Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4

Science

An eosinophil-dependent mechanism for the antitumor effect of interleukin-4

Science

In vitro and in vivo growth of B16F10 melanoma cells transfected with interleukin-4 cDNA and gene therapy with the transfectant

J. Cancer Res. Clin. Oncol.

Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer

Hum. Gene Ther.

Fibrosarcoma cells transduced with the IL-6 gene exhibit reduced tumorigenicity, increased immunogenicity, and decreased metastatic potential

Cancer Res.

Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells

Cancer Res.