The enteric nervous system participates in the secretory response to the heat stable enterotoxins of Escherichia coli in rats and cats
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Cited by (79)
Deciphering ion transporters, kinases and PDZ-adaptor molecules that mediate guanylate cyclase C agonist-dependent intestinal fluid loss in vivo
2020, Biochemical PharmacologyCitation Excerpt :Studies in heterologous expression systems and isolated intestinal mucosa carefully delineated the STa-induced enterocyte signaling pathways, indicating that different PDZ-adaptor molecules from the NHERF family of PDZ-adaptors play a role in both CFTR activation and NHE3 inhibition [4,7,13,14]. In vivo studies in rats and cats, however, suggested that a major diarrheagenic effect of STa was mediated via neural transduction [22,43] as well. For decades, pharmacological strategies have been developed to target the key components of the STa-mediated secretory diarrhea, so far with insufficient efficacy and specificity [5,15,33,59,60].
Escherichia coli heat-stable enterotoxins
2015, The Comprehensive Sourcebook of Bacterial Protein ToxinsEnteric Nervous System Structure and Neurochemistry Related to Function and Neuropathology
2012, Physiology of the Gastrointestinal Tract, Two Volume SetEnteric Nervous System Structure and Neurochemistry Related to Function and Neuropathology
2012, Physiology of the Gastrointestinal TractPathophysiology of Diarrhea in Calves
2009, Veterinary Clinics of North America - Food Animal PracticeCitation Excerpt :STa-mediated secretion may also involve local reflex arcs in the enteric nervous system (ENS); however, it does not involve the autonomic nervous system.43 Most of the support for this idea comes from studies that inhibit the ENS and subsequently reduce the secretory effect of STa.44–46 The neurotransmitters critical in these responses are nitric oxide (NO) and VIP,40,46 whereas PGE2 and 5-HT are not involved.41 Furthermore, a well-defined example of the influence of the ENS in ETEC is its role in exacerbating STa-mediated secretory diarrhea in states of malnutrition,47–49 however the importance of these mechanisms in the calf is unknown because this was found in a rodent model of human disease.
Morphological relationships between peptidergic nerve fibers and immunoglobulin A-producing lymphocytes in the mouse intestine
2008, Brain, Behavior, and ImmunityCitation Excerpt :The enteric nervous system has various intrinsic reflex systems (Furness, 2006). The secretomotor reflexes are caused by the intraluminal administration of toxins such as cholera toxin (Cassuto et al., 1981a) and enterotoxins (Eklund et al., 1985), or infectious pathogens such as Salmonella (Brunsson, 1987),Cryptosporisium (Argenzio et al., 1996), and rotavirus (Lundgren et al., 2000). The secretion of VIP from the small intestine is increased by exposure to cholera toxin (Cassuto et al., 1981b) and VIP has an important role as the putative transmitter in intestinal secretion induced by toxins (Mourad and Nassar, 2000).
The present research was supported by grants from the Swedish Medical Research Council (2855), from the Swedish Society of Medical Sciences, from the Faculty of Medicine, University of Göteborg, from Magnus Bergvall's Foundation and from the Astra Research Foundation.