Calcitonin gene-related peptide-α receptor binding sites in the gastrointestinal tract
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The two-faced effects of nerves and neuropeptides in corneal diseases
2022, Progress in Retinal and Eye ResearchCitation Excerpt :Besides orchestrating a local response, stimulation of corneal nerve terminals can also elicit an inflammatory response in distant targets such as the TG and in the CNS. For instance, it has been reported that sensory neuropeptides are involved in the propagation of the inflammatory response to the CNS, following application of a peripheral noxious stimulus (Gates et al., 1989). In this vein, acute damage of corneal nerves results in TG inflammation, as demonstrated by leukocyte migration along the trigeminal nerve (Ferrari et al., 2014) (Fig. 6, A), and by in vivo detection of leukocyte accumulation in the TG (Fig. 6, B).
CGRP
2013, Handbook of Biologically Active PeptidesLocalization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract
2012, PeptidesCitation Excerpt :To characterize these functions, murine localization studies have shown α-CGRP to be localized within spinal afferent Aδ and C fibers of dorsal root ganglia [27], and β-CGRP within the enteric nervous system [32,33]. Binding sites for radiolabeled CGRP are present within the myenteric plexus of both dogs [8] and rats [25]. Immunolocalization studies in rat intestine show CLR expression in nerve fibers of the muscularis externa and myenteric and submucosal plexuses [6].
Neural Regulation of Gastrointestinal Blood Flow
2012, Physiology of the Gastrointestinal Tract, Two Volume SetNeural Regulation of Gastrointestinal Blood Flow
2012, Physiology of the Gastrointestinal Tract