Assignment of defensin gene(s) to human chromosome 8p23
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Cited by (77)
Alarmin human α defensin HNP1 activates plasmacytoid dendritic cells by triggering NF-κB and IRF1 signaling pathways
2016, CytokineCitation Excerpt :Alarmin human neutrophil peptide 1 (HNP1) is one of the four neutrophil-derived α defensins initially isolated from the azurophilic granules of human neutrophils [1,2]. HNP1, encoded by the DEFA1 gene located on human chromosome 8p23.1 [3,4], is predominantly expressed by cells of human neutrophil lineage, although it is also present in other cell types such as human NK, T cells, myeloid DCs, eosinophils, and synovial membrane of human joints [1,2,5–8]. In neutrophil lineage, HNP1 is translated in promyelocytes as a 94 amino acid preproform and sequentially cleaved in the Golgi body into a 30 amino acid mature HNP1 that is sorted and stored in the azurophilic (primary) granules of mature neutrophils [9,10].
Defensins in Enteric Mucosal Immunity
2015, Mucosal Immunology: Fourth EditionMammalian Antimicrobial Peptides; Defensins and Cathelicidins
2014, Molecular Medical MicrobiologyDefensins: Natural component of human innate immunity
2013, Human ImmunologyCitation Excerpt :The first human β-defensins were identified in 1995 as trace peptides in blood filtrates [27] (see Fig. 2). The genes of all known human α-defensins are located on chromosome 8p23 [28–30] about 100–150 kb from the β-defensin 1 gene [31]. The genes that encode human α-defensins 1, 2 and 3 (DEFA-1, DEFA-2 and DEFA-3) each have a length of about 3 kb and contain three exons while genes of human α-defensins 5 and 6, also known as enteric defensins, consist of 2 exons that encode the signal and mature peptide [32].
Paneth Cell α-Defensins
2013, Handbook of Biologically Active PeptidesPaneth Cells
2012, Physiology of the Gastrointestinal Tract, Two Volume Set