Elsevier

Genomics

Volume 5, Issue 2, August 1989, Pages 240-244
Genomics

Assignment of defensin gene(s) to human chromosome 8p23

https://doi.org/10.1016/0888-7543(89)90052-9Get rights and content

Abstract

A relatively abundant component of the polymorphonuclear leukocyte granulocytes has been recently isolated and called defensin. Defensins have antimicrobial activity against gram-positive and gram-negative bacteria and enveloped viruses. A cDNA insert for defensin HNP-1 (DEF1) has been used to map the gene(s) to human chromosome 8p23 using a mouse/human somatic cell hybrid panel and in situ hybridization to normal human metaphase chromosomes. Because of the similarity of HNP-1 defensin to other defensins, it is likely that two of these genes map to this region.

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