Adenovirus vectors for gene expression

https://doi.org/10.1016/0958-1669(91)90041-3Get rights and content

Abstract

Adenoviruses possess a combination of features that make them highly suitable as vectors for expression of heterologous genes. Non-conditional and non-defective adeno-vectors have been constructed to obtain high level expression of a number of foreign genes and some of them have been shown in animal models to exhibit excellent promise as vaccine candidates.

References (27)

  • D Hanahan et al.

    Rescue of Functional Replication Origins from Embedded Configurations in a Plasmid Carrying the Adenovirus Genome

    Mol Cell Biol

    (1984)
  • N Lamarche et al.

    High Level Expression in 293 Cells of the Herpes Simplex Virus Type 2 Ribonucleotide Reductase Subunit 2 Using an Adenovirus Vector

    J Gen Virol

    (1990)
  • X Zhu et al.

    Reactivation of Latent Herpes Simplex Virus by Adenovirus Recombinants Encoding Mutant IE-O Gene Products

    J Virol

    (1990)
  • Cited by (21)

    • Delivery of nucleic acid drugs

      2012, Advances in Polymer Science
    View all citing articles on Scopus
    View full text