Review
Okadaic acid: a new probe for the study of cellular regulation

https://doi.org/10.1016/0968-0004(90)90192-EGet rights and content

Abstract

The tumour promoter okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A. Here we review recent studies which demonstrate that this toxin is extremely useful for identifying biological processes that are controlled through the reversible phosphorylation of proteins.

References (44)

  • A. Takai et al.

    FEBS Lett.

    (1987)
  • P. Cohen et al.

    J. Biol. Chem.

    (1989)
  • P. Cohen et al.

    FEBS Lett.

    (1989)
  • P. Cohen et al.

    FEBS Lett.

    (1989)
  • C.G. Proud

    Trends Biochem. Sci.

    (1986)
  • A.G. Ryazanov

    FEBS Lett.

    (1987)
  • A.C. Nairn et al.

    J. Biol. Chem.

    (1987)
  • J. Haavik et al.

    FEBS Lett.

    (1989)
  • K. Ohuchi et al.

    Biochim. Biophys. Acta

    (1989)
  • G.L. Johnson
  • H. Ishihara et al.

    Biochem. Biophys. Res. Commun.

    (1989)
  • T. Sassa et al.

    Biochem. Biophys. Res. Commun.

    (1989)
  • K. Tachibana et al.

    J. Am. Chem. Soc.

    (1981)
  • F.J. Schmitz et al.

    J. Am. Chem. Soc.

    (1981)
  • Y. Murakami et al.

    Bull. Jpn Soc. Sci. Fish.

    (1981)
  • T. Yasumoto et al.
  • T. Yasumoto et al.

    Bull. Jpn Soc. Sci. Fish.

    (1978)
  • T. Yasumoto et al.

    Tetrahedron

    (1985)
  • S. Shibata et al.

    J. Pharmacol. Exp. Ther.

    (1982)
  • C. Bialojan et al.

    Biochem. J.

    (1988)
  • P. Cohen

    Annu. Rev. Biochem.

    (1989)
  • T.J. Haystead et al.

    Nature

    (1989)
  • Cited by (0)

    View full text