Original contributionTumor necrosis factor-α gene expression in the tissues of normal mice
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2011, TheriogenologyCitation Excerpt :One potential regulator of ovarian follicular development is tumor necrosis factor α (TNFα), a 17.3 kDa protein product of activated macrophages, first identified as an inducer of necrosis of certain tumors in vivo [3–6]. Numerous cell types contain TNFα, including osteoblasts, keratinocytes, astrocytes, hepatocytes, kidney tubule epithelial cells, spleen cells [7], and cells of both uterus and placenta [8,9]. Tumor necrosis factor α has also been identified within the ovaries of many species, including rabbits [10,11], humans [12], mice [9] and rats [13].
Differential regulation of TNF receptors by vagal nerve stimulation protects heart against acute ischemic injury
2010, Journal of Molecular and Cellular CardiologyCitation Excerpt :An elegant study by Borovikova et al, demonstrated the inhibition of tumor necrosis factor-α (TNF-α) in the liver as one possible mechanism behind the anti inflammatory effect afforded by efferent VS [6]. Tumor necrosis factor-α is a proinflammatory cytokine with pleiotropic biological effects that has been demonstrated to produce either adaptive homeostatic responses or devastating maladaptive effects, depending on the duration and degree to which this cytokine is expressed [7,8]. Interestingly, our preliminary studies showed a marked increase in the TNF-α mRNA with VS treatment after 30 min of acute ischemia (supplemental Fig. 1).
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