The International Journal of Biochemistry & Cell Biology
ReviewPolyamine transport in mammalian cells. An update
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2024, Sensors and Actuators B: ChemicalSpermidine alleviates heat shock and promotes the growth of Bombyx mori
2022, Journal of Thermal BiologyCitation Excerpt :Thus, to address the issue, there is a need to identify molecules that improve thermotolerance in B. mori to enhance silk production. Putrescine, spermidine (Spd), and spermine, which are polyamines found in all species (Bachrach, 2010), are critical regulators of mammalian growth, gene transcription, and ribosome-mediated translation (Childs et al., 2003; Seiler et al., 1996). Additionally, polyamines play an important role in the development and differentiation of sexual organs (Shubhada et al., 1989) and cell proliferation, differentiation, and apoptosis (Kusano et al., 2007; Liu et al., 2005; Nakamura et al., 2021).
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2022, Biochimica et Biophysica Acta - Molecular Cell ResearchESIPT-active hydroxybenzothiazole-picolinium@CB[7]-HAp NPs based supramolecular sensing assembly for spermine, spermidine and cadaverine: Application in monitoring cancer biomarkers and food spoilage
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2021, Cancer LettersCitation Excerpt :The polyamines, putrescine, spermidine, and spermine, are essential for cellular growth and critical functions, such as embryonic development, differentiation, and proliferation. Polyamines are aliphatic amines that are positively charged at the physiological pH [1–3] and their homeostasis requires strict regulation to support normal cellular functions [4]. Polyamines accumulate at high levels in tissues undergoing rapid growth and dysregulated polyamine biosynthesis correlates with the development of several pathological states, such as Alzheimer disease, and cancer [4–6].
Synthesis and biological evaluation of chalcone-polyamine conjugates as novel vectorized agents in colorectal and prostate cancer chemotherapy
2021, European Journal of Medicinal Chemistry