Infection imaging with technetium-99m-labeled chemotactic peptide analogs*
References (43)
- et al.
Clinical experience with 99mTc-hexamethylpropyleneamineoxime for labeling leukocytes and imaging inflammation
Lancet
(1986) - et al.
Detection of acute inflammation with 111In-labeled non-specific polyclonal IgG
Semin Nucl Med
(1988) - et al.
Covalent affinity labeling of the formyl peptide chemotactic receptor
J Biol Chem
(1980) - et al.
Leukocyte chemoattractant receptors
Methods Enzymol
(1988) - et al.
Chemoattractant-mediated stimulation of the respiratory burst in human polymorphonuclear leukocytes may require appearance of protein kinase activity in the cells, particulate fraction
Blood
(1986) - et al.
Techniques of leukocyte harvesting and labeling: Problems and perspectives
Semin Nucl Med
(1984) - et al.
Neutrophil labeling: Problems and pitfalls
Semin Nucl Med
(1984) - et al.
Technetium-99m HM-PAO-labeled leukocytes in detection of inflammatory lesions: Comparison with gallium-67 citrate
J Nucl Med
(1989) - et al.
Appendicitis: Evaluation by Tc-99m leukocyte scan
Ann Emerg Med
(1988) - et al.
Failure of zidovudine prophylaxis after accidental exposure to HIV-1
N Engl J Med
(1990)
Health officials reacting to infection mishaps
J Nucl Med
Imaging of inflammatory lesions after injection of radioiodinated monoclonal antigranulocyte antibodies
Nucl Med Commun
111Inlabeled nonspecific immunoglobulin scanning in the detection of focal infection
New Engl J Med
In search of the hot appendix—A clinicians view on inflammation imaging
J Nucl Med
Role of iron-binding proteins and enhanced vascular permeability in the accumulation of gallium-67
J Nucl Med
Platelet factor 4 is chemoattractant for neutrophils and monocytes
Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils
J Clin Invest
The structural relations of synthetic peptides as chemotactic factors and inducers of lysosomal enzyme secretion for neutrophils
J Exp Med
Formylmethionyl peptides as chemoattractants for leukocytes
Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes
Leukocyte activation by chemoattractant receptors: Roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism
Rev Infect Dis
Cited by (62)
Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail
2018, Seminars in Nuclear MedicineCitation Excerpt :Ten years later, Fishman et al prepared FMLP analogs, labeled them with 99mTc. Further investigations in animals witnessed persistent neutropenia.134-137 Chemokines are signaling proteins secreted by cells.
<sup>99M</sup>TC-Ceftizoxzime scintigraphy in normal rats and abscess induced rats
2005, Revista Espanola de Medicina Nuclear<sup>99m</sup>Tc-Alafosfalin: An antibiotic peptide infection imaging agent
2003, Nuclear Medicine and Biology<sup>99m</sup>Tc-labeling experiments on CCK<inf>4</inf> by a direct method
2001, Nuclear Medicine and BiologyCitation Excerpt :Because of the pharmacological potency of some of these peptides and the sometimes low receptor density, radiolabeling with high specific activity is required to reduce untoward effects from the amount of peptide [5,18]. Several indirect labeling methods for peptides have been developed, mostly based upon the use of bifunctional chelators and ligands, serving as a linker molecule between the biological active compound and the radionuclide [5,6,9,18,19]. Also direct labeling of peptides with radiometals has been reported with good results [20], which encompass a binding of the radiometal to amide, thiol, carboxylate or amino donor groups in the peptide.
Imaging of infectious arthritis
2001, Radiologic Clinics of North AmericaRole of scintigraphy in musculoskeletal and spinal infections
2001, Radiologic Clinics of North AmericaCitation Excerpt :In preliminary studies, chemotactic peptides have been labeled with In 111 and Tc 99m and have shown accumulation in nonsterile inflammation. Side effects and labeling problems, however, are hampering their development.21 Liposomes are microscopic lipid vesicles and have been used for tumor imaging and drug delivery.
- *
Supported in part by grants from the R. W. Johnson Pharmaceutical Research Institute and the Shriners, Hospitals for Crippled Children.